Habbick B F, Blakley P M, Houston C S, Snyder R E, Senthilselvan A, Nanson J L
Alvin Buckwold Child Development Program, Kinsmen Children's Centre, Royal University Hospital, Saskatoon, Saskatchewan, Canada.
Alcohol Clin Exp Res. 1998 Sep;22(6):1312-6.
We have found delayed mean bone age in 63 children with fetal alcohol syndrome (FAS). The mean bone age Z-score for boys (n = 31) was -2.12 SDs and for girls (n = 32) was -1.62 SDs. This might suggest that they have potential for catch-up growth. However, experience with children with intrauterine growth retardation suggests that this will not be the case and that FAS children will be of reduced height at maturity. Further support for this assumption was gained from a sample of 26 patients who were followed until at least the age of 14 years for females and 16 years for males. There was no significant change in height Z-scores from early childhood to early adulthood, the mean score being -2.16 SDs and -2.11 SDs at mean ages of 4.83 years and 18.69 years, respectively. On the other hand, there were significant changes in weight and head circumference. The mean weight Z-score changed from -2.10 SDs to -1.14 SDs (p < 0.001). The head circumference mean Z-score in 16 patients was -3.13 SDs at a mean age of 2.79 years and -2.63 SDs at a mean age of 17.37 years (p = 0.013). Short stature can continue to be used as a diagnostic criterion for FAS beyond childhood.
我们发现63名患有胎儿酒精综合征（FAS）的儿童骨龄均值延迟。男孩（n = 31）的骨龄Z值平均为 -2.12标准差，女孩（n = 32）为 -1.62标准差。这可能表明他们有追赶生长的潜力。然而，对宫内生长迟缓儿童的研究经验表明情况并非如此，FAS儿童成年后身高会降低。对这一假设的进一步支持来自于对26名患者的样本研究，这些患者至少被跟踪到女性14岁、男性16岁。从幼儿期到成年早期，身高Z值没有显著变化，平均年龄4.83岁和18.69岁时的平均分数分别为 -2.16标准差和 -2.11标准差。另一方面，体重和头围有显著变化。平均体重Z值从 -2.10标准差变为 -1.14标准差（p < 0.001）。16名患者的头围平均Z值在平均年龄2.79岁时为 -3.13标准差，在平均年龄17.37岁时为 -2.63标准差（p = 0.013）。身材矮小在儿童期之后仍可继续作为FAS的诊断标准。
