使用单独的标记线圈对脑灌注区域进行动脉自旋标记。
Arterial spin labeling of cerebral perfusion territories using a separate labeling coil.
作者信息
Paiva Fernando F, Tannús Alberto, Talagala S Lalith, Silva Afonso C
机构信息
Cerebral Microcirculation Unit, Laboratory of Functional and Molecular Imaging, National Institute of Neurological Disorders and Stroke (NINDS), National Institutes of Health (NIH), Bethesda, Maryland, USA.
出版信息
J Magn Reson Imaging. 2008 May;27(5):970-7. doi: 10.1002/jmri.21320.
PURPOSE
To obtain cerebral perfusion territories of the left, the right, and the posterior circulation in humans with high signal-to-noise ratio (SNR) and robust delineation.
MATERIALS AND METHODS
Continuous arterial spin labeling (CASL) was implemented using a dedicated radio frequency (RF) coil, positioned over the neck, to label the major cerebral feeding arteries in humans. Selective labeling was achieved by flow-driven adiabatic fast passage and by tilting the longitudinal labeling gradient about the Y-axis by theta = +/- 60 degrees .
RESULTS
Mean cerebral blood flow (CBF) values in gray matter (GM) and white matter (WM) were 74 +/- 13 mL . 100 g(-1) . minute(-1) and 14 +/- 13 mL . 100 g(-1) . minute(-1), respectively (N = 14). There were no signal differences between left and right hemispheres when theta = 0 degrees (P > 0.19), indicating efficient labeling of both hemispheres. When theta = +60 degrees , the signal in GM on the left hemisphere, 0.07 +/- 0.06%, was 92% lower than on the right hemisphere, 0.85 +/- 0.30% (P < 1 x 10(-9)), while for theta = -60 degrees , the signal in the right hemisphere, 0.16 +/- 0.13%, was 82% lower than on the contralateral side, 0.89 +/- 0.22% (P < 1 x 10(-10)). Similar attenuations were obtained in WM.
CONCLUSION
Clear delineation of the left and right cerebral perfusion territories was obtained, allowing discrimination of the anterior and posterior circulation in each hemisphere.
目的
获得具有高信噪比（SNR）且轮廓清晰的人类左、右和后循环脑灌注区域。
材料与方法
采用置于颈部上方的专用射频（RF）线圈实施连续动脉自旋标记（CASL），以标记人类大脑的主要供血动脉。通过流动驱动的绝热快速通过以及将纵向标记梯度绕Y轴倾斜θ = +/- 60度实现选择性标记。
结果
灰质（GM）和白质（WM）的平均脑血流量（CBF）值分别为74 +/- 13 mL·100 g⁻¹·分钟⁻¹和14 +/- 13 mL·100 g⁻¹·分钟⁻¹（N = 14）。当θ = 0度时，左右半球之间无信号差异（P > 0.19），表明两个半球均标记有效。当θ = +60度时，左半球GM中的信号为0.07 +/- 0.06%，比右半球的0.85 +/- 0.30%低92%（P < 1 x 10⁻⁹），而当θ = -60度时，右半球的信号为0.16 +/- 0.13%，比另一侧的0.89 +/- 0.22%低82%（P < 1 x 10⁻¹⁰）。WM中也获得了类似的衰减。
结论
获得了左右脑灌注区域的清晰轮廓，能够区分每个半球的前循环和后循环。
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