2型糖尿病患者中1,5-脱水葡萄糖醇与餐后2小时血糖的关联
Association of 1,5-anhydroglucitol and 2-h postprandial blood glucose in type 2 diabetic patients.
作者信息
Stettler Christoph, Stahl Matthias, Allemann Sabin, Diem Peter, Schmidlin Kurt, Zwahlen Marcel, Riesen Walter, Keller Ulrich, Christ Emanuel
机构信息
Division of Endocrinology, Diabetes, and Clinical Nutrition, University Hospital, Bern, Switzerland.
出版信息
Diabetes Care. 2008 Aug;31(8):1534-5. doi: 10.2337/dc08-0385. Epub 2008 Apr 21.
OBJECTIVE
To assess the association of 1,5-anhydroglucitol (1,5-AG) with 2-h postprandial glucose values in type 2 diabetic patients followed over 12 months in an outpatient setting.
RESEARCH DESIGN AND METHODS
In 55 patients, we examined self-measured postprandial blood glucose values for correlations with 1,5-AG values over prespecified preceding time periods (3 days, 1 week, and weekly up to 12 weeks).
RESULTS
The correlation coefficients for postprandial glucose values were -0.34 (P < 0.05) for 3 days, -0.38 (P < 0.001) for 1 week, and -0.40 (P < 0.001) for 2 weeks preceding the measurement of 1,5-AG. Correlations declined for time periods >2 weeks before measurement of 1,5-AG. The correlation was lower with fasting/preprandial plasma glucose levels. There was no time dependency for the correlation between A1C and fasting or postprandial glucose.
CONCLUSIONS
1,5-AG best reflected the 2-h postprandial glucose values of the 2 previous weeks.
目的
评估门诊环境下随访12个月的2型糖尿病患者中1,5-脱水葡萄糖醇（1,5-AG）与餐后2小时血糖值之间的关联。
研究设计与方法
在55例患者中，我们检查了自我测量的餐后血糖值，以确定其与预先指定的之前时间段（3天、1周以及直至12周每周）的1,5-AG值之间的相关性。
结果
在测量1,5-AG之前，餐后血糖值的相关系数在3天为-0.34（P<0.05），1周为-0.38（P<0.001），2周为-0.40（P<0.001）。在测量1,5-AG之前超过2周的时间段，相关性下降。与空腹/餐前血浆葡萄糖水平的相关性较低。糖化血红蛋白（A1C）与空腹或餐后血糖之间的相关性不存在时间依赖性。
结论
1,5-AG最能反映前两周的餐后2小时血糖值。
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