Bortolotto Z A, Anderson W W, Isaac J T, Collingridge G L
MRC Centre for Synaptic Plasticity, Bristol, United Kingdom.
Curr Protoc Neurosci. 2001 Nov;Chapter 6:Unit 6.13. doi: 10.1002/0471142301.ns0613s16.
Synaptic plasticity is the process by which the brain alters the strength of its synaptic connections, a fundamental function of the brain that enables individuals to learn from experience. The study of synaptic plasticity often involves the application of standard in vitro electrophysiological techniques to hippocampal slice preparations. This unit discusses many of the special considerations that are applicable for the optimal study of synaptic plasticity in this system. Most of these principles also apply to the study of synaptic plasticity in other brain slice preparations.
突触可塑性是大脑改变其突触连接强度的过程,这是大脑的一项基本功能,使个体能够从经验中学习。对突触可塑性的研究通常涉及将标准的体外电生理技术应用于海马切片标本。本单元讨论了许多适用于该系统中突触可塑性最佳研究的特殊注意事项。这些原则中的大多数也适用于其他脑切片标本中突触可塑性的研究。