Schwarz Erich M, Sternberg Paul W
California Institute of Technology, Pasadena, California, USA.
Curr Protoc Bioinformatics. 2006 Jul;Chapter 1:Unit 1.8. doi: 10.1002/0471250953.bi0108s14.
WormBase is the major public biological database for the nematode Caenorhabditis elegans. It is meant to be useful to any biologist who wants to use C. elegans, whatever his or her specialty. WormBase contains information about the genomic sequence of C. elegans, its genes and their products, and its higher-level traits such as gene expression patterns and neuronal connectivity. WormBase also contains genomic sequences and gene structures of C. briggsae and C. remanei, two closely related worms. These data are interconnected, so that a search beginning with one object (such as a gene) can be directed to related objects of a different type (e.g., the DNA sequence of the gene or the cells in which the gene is active). One can also perform searches for complex data sets. The WormBase developers group actively invites suggestions for improvements from the database users. WormBase's source code and underlying database are freely available for local installation and modification.
WormBase是线虫秀丽隐杆线虫的主要公共生物学数据库。它旨在对任何想要使用秀丽隐杆线虫的生物学家有用,无论其专业是什么。WormBase包含秀丽隐杆线虫的基因组序列、其基因及其产物的信息,以及其更高层次的特征,如基因表达模式和神经元连接性。WormBase还包含两种密切相关的线虫——嗜热栖热放线菌和雷曼隐杆线虫的基因组序列和基因结构。这些数据相互关联,因此从一个对象(如一个基因)开始的搜索可以指向不同类型的相关对象(例如该基因的DNA序列或该基因活跃的细胞)。人们还可以搜索复杂的数据集。WormBase开发团队积极邀请数据库用户提出改进建议。WormBase的源代码和基础数据库可免费用于本地安装和修改。