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没有什么地方能像WormBase这样:它是秀丽隐杆线虫研究人员不可或缺的资源。

There's no place like WormBase: an indispensable resource for Caenorhabditis elegans researchers.

作者信息

O'Connell Kevin

机构信息

Laboratory of Biochemistry and Genetics, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA.

出版信息

Biol Cell. 2005 Nov;97(11):867-72. doi: 10.1042/BC20040155.

Abstract

The nematode Caenorhabditis elegans is used extensively by scientists to study a wide variety of biological processes and is one of the most thoroughly characterized animals. Over the years, the community of C. elegans researchers has generated a wealth of information on the genetics, development, behaviour, and cellular and molecular biology of the worm. This body of data has grown even larger with the recent application of high throughput screening methodology to study gene function, expression and interactions. WormBase (http://www.wormbase.org) is the primary online source of biological data on C. elegans and related nematodes. Equipped with an assortment of powerful search tools, WormBase allows users to quickly extract a variety of information, including data on individual genes, DNA sequence, cell lineage and literature citations. As the database is well maintained and the functionalities constantly modified in response to evolving researcher needs, WormBase has become a vital component of the laboratories studying the worm and a model for other biological databases.

摘要

线虫秀丽隐杆线虫被科学家广泛用于研究各种各样的生物过程,是特征描述最为详尽的动物之一。多年来,秀丽隐杆线虫研究群体已经积累了关于这种线虫的遗传学、发育、行为以及细胞与分子生物学等方面的大量信息。随着高通量筛选方法最近应用于研究基因功能、表达及相互作用,这一数据体量变得更加庞大。WormBase(http://www.wormbase.org)是关于秀丽隐杆线虫及相关线虫的生物学数据的主要在线来源。配备了各种强大的搜索工具,WormBase允许用户快速提取各种信息,包括单个基因的数据、DNA序列、细胞谱系和文献引用。由于该数据库维护良好,并且其功能会根据研究人员不断变化的需求持续修改,WormBase已成为研究线虫的实验室的重要组成部分,也是其他生物数据库的典范。

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