Madden Jeanne M, Graves Amy J, Zhang Fang, Adams Alyce S, Briesacher Becky A, Ross-Degnan Dennis, Gurwitz Jerry H, Pierre-Jacques Marsha, Safran Dana Gelb, Adler Gerald S, Soumerai Stephen B
Department of Ambulatory Care and Prevention, Harvard Medical School and Harvard Pilgrim Health Care, 133 Brookline Ave, 6th Floor, Boston, Massachusetts 02215, USA.
JAMA. 2008 Apr 23;299(16):1922-8. doi: 10.1001/jama.299.16.1922.
Cost-related medication nonadherence (CRN) has been a persistent problem for individuals who are elderly and disabled in the United States. The impact of Medicare prescription drug coverage (Part D) on CRN is unknown.
To estimate changes in CRN and forgoing basic needs to pay for drugs following Part D implementation.
DESIGN, SETTING, AND PARTICIPANTS: In a population-level study design, changes in study outcomes between 2005 and 2006 before and after Medicare Part D implementation were compared with historical changes between 2004 and 2005. The community-dwelling sample of the nationally representative Medicare Current Beneficiary Survey (unweighted unique n = 24,234; response rate, 72.3%) was used, and logistic regression analyses were controlled for demographic characteristics, health status, and historical trends.
Self-reports of CRN (skipping or reducing doses, not obtaining prescriptions) and spending less on basic needs to afford medicines.
The unadjusted, weighted prevalence of CRN was 15.2% in 2004, 14.1% in 2005, and 11.5% after Part D implementation in 2006. The prevalence of spending less on basic needs was 10.6% in 2004, 11.1% in 2005, and 7.6% in 2006. Adjusted analyses comparing 2006 with 2005 and controlling for historical changes (2005 vs 2004) demonstrated significant decreases in the odds of CRN (ratio of odds ratios [ORs], 0.85; 95% confidence interval [CI], 0.74-0.98; P = .03) and spending less on basic needs (ratio of ORs, 0.59; 95% CI, 0.48-0.72; P < .001). No significant changes in CRN were observed among beneficiaries with fair to poor health (ratio of ORs, 1.00; 95% CI, 0.82-1.21; P = .97), despite high baseline CRN prevalence for this group (22.2% in 2005) and significant decreases among beneficiaries with good to excellent health (ratio of ORs, 0.77; 95% CI, 0.63-0.95; P = .02). However, significant reductions in spending less on basic needs were observed in both groups (fair to poor health: ratio of ORs, 0.60; 95% CI, 0.47-0.75; P < .001; and good to excellent health: ratio of ORs, 0.57; 95% CI, 0.44-0.75; P < .001).
In this survey population, there was evidence for a small but significant overall decrease in CRN and forgoing basic needs following Part D implementation. However, no net decrease in CRN after Part D was observed among the sickest beneficiaries, who continued to experience higher rates of CRN.
在美国,与费用相关的药物治疗不依从(CRN)一直是老年人和残疾人面临的一个长期问题。医疗保险处方药覆盖范围(D部分)对CRN的影响尚不清楚。
评估D部分实施后CRN的变化以及为支付药费而放弃基本需求的情况。
设计、地点和参与者:在一项基于人群的研究设计中,将2005年至2006年医疗保险D部分实施前后研究结果的变化与2004年至2005年的历史变化进行比较。使用具有全国代表性的医疗保险当前受益人调查中的社区居住样本(未加权的唯一样本量n = 24,234;回复率72.3%),并对人口统计学特征、健康状况和历史趋势进行逻辑回归分析。
CRN的自我报告(跳过或减少剂量、未获取处方)以及为负担药物而在基本需求上支出减少。
2004年未经调整的加权CRN患病率为15.2%,2005年为14.1%,2006年D部分实施后为11.5%。在基本需求上支出减少的患病率在2004年为10.6%,2005年为11.1%,2006年为7.6%。将2006年与2005年进行比较并控制历史变化(2005年与2004年)的调整分析显示,CRN的几率显著降低(优势比[OR]比值为0.85;95%置信区间[CI]为0.74 - 0.98;P = 0.03),且在基本需求上支出减少的几率也显著降低(OR比值为0.59;95% CI为0.48 - 0.72;P < 0.001)。健康状况为一般至较差的受益人中未观察到CRN的显著变化(OR比值为1.00;95% CI为0.82 - 1.21;P = 0.97),尽管该组的基线CRN患病率较高(2005年为22.