Soumaré M, Seydi M, Dia N M, Diop S A, N'dour C T, Diouf L, Diop B M, Sow P S
Clinique des maladies infectieuses, CHU de Fann, BP 5035 Dakar, Sénégal.
Bull Soc Pathol Exot. 2008 Feb;101(1):54-7.
This study aimed at describing the epidemiology, clinical features and prognosis of post-circumcision tetanus at the infectious diseases clinic in Fann Hospital in Dakar. Data were collected retrospectively for analysis from patients' files recorded from January 1, 1999 to December 31, 2006. 54 cases were included, accounting for 4% of all tetanus cases admitted to the clinic during the study period (54 cases/1291). The patients' average age was 9 +/- 3.7 years old (range = 1-17 years) and 52% of them were schoolboys. In most cases (76%), tetanus symptoms occurred beyond 7 days after circumcision. The average delay from onset of the disease to admission was 2.3 days (range = 0-6 days). The circumcision took place at home in 39% of cases, in health center in 35% of cases and in unspecified area in 26% of cases. The majority of patients (85%) had never received tetanus vaccine and, in 72% of the cases, the circumciser was designated as a male nurse. Generalized tetanus was observed in all cases, most of which was a mild form of the disease (63%). During hospitalisation, thirteen patients (24%) had complications among which diaphragmatic and intercostal muscle spasms (3 cases), bacteraemia (5 cases), respiratory infection (4 cases), urinary tract infection (4 cases), and fracture of the vertebrae (1 case). The case fatality rate was 7.4% (4 deaths). Vaccination together with health education of the population as well as a better sensitization of the practitioners are necessary to eradicate tetanus after circumcision.
本研究旨在描述达喀尔法恩医院传染病门诊包皮环切术后破伤风的流行病学、临床特征及预后。回顾性收集了1999年1月1日至2006年12月31日记录在案的患者病历资料进行分析。共纳入54例病例,占研究期间该门诊收治的所有破伤风病例的4%(54例/1291例)。患者平均年龄为9±3.7岁(范围为1 - 17岁),其中52%为男学生。在大多数病例中(76%),破伤风症状在包皮环切术后7天以上出现。从疾病发作到入院的平均延迟时间为2.3天(范围为0 - 6天)。39%的病例在家中进行包皮环切,35%在卫生中心进行,26%在未明确的地点进行。大多数患者(85%)从未接种过破伤风疫苗,72%的病例中实施包皮环切术者为男护士。所有病例均为全身性破伤风,其中大多数为轻症(63%)。住院期间,13例患者(24%)出现并发症,其中膈肌和肋间肌痉挛(3例)、菌血症(5例)、呼吸道感染(4例)、尿路感染(4例)以及脊椎骨折(1例)。病死率为7.4%(4例死亡)。为根除包皮环切术后破伤风,有必要对人群进行疫苗接种和健康教育,并提高从业者的认识。