一名接受高效抗逆转录病毒治疗且患有播散性非结核分枝杆菌感染的艾滋病患者发生回肠末端自发性穿孔。

Spontaneous perforation of the terminal ileum in an AIDS patient on highly active antiretroviral therapy with disseminated non-tuberculous mycobacterial infection.

作者信息

Kawana Masataka, Starr Rebecca S, Tashima Karen T, Treaba Diana O, Flanigan Timothy P

机构信息

Department of Medicine, The Warren Alpert Medical School of Brown University, Providence, Rhode Island, USA.

出版信息

Int J Infect Dis. 2008 Nov;12(6):603-6. doi: 10.1016/j.ijid.2007.12.013. Epub 2008 Apr 22.

DOI:10.1016/j.ijid.2007.12.013

PMID:18434225

Abstract

BACKGROUND

Despite the impact of highly active antiretroviral therapy (HAART), mycobacterial infections in patients with AIDS remain a frequent complication. In disseminated cases, both tuberculous and non-tuberculous mycobacterial infections may involve the gastrointestinal system and cause abdominal pain and diarrhea. While there have been cases of small bowel perforation in AIDS patients with Mycobacterium tuberculosis (MTB) infection, no case of bowel perforation in non-tuberculous mycobacterial (NTM) infection has been reported to date.

CASE REPORT

We report a case of spontaneous perforation of the terminal ileum in an AIDS patient with disseminated non-tuberculous mycobacterial infection who was responding to HAART.

CONCLUSIONS

Non-tuberculous mycobacteria can lead to spontaneous bowel perforation in patients with AIDS who are responding to HAART.

摘要

背景

尽管高效抗逆转录病毒疗法（HAART）有一定作用，但艾滋病患者的分枝杆菌感染仍是常见并发症。在播散性病例中，结核分枝杆菌和非结核分枝杆菌感染均可累及胃肠道系统，引起腹痛和腹泻。虽然有艾滋病合并结核分枝杆菌（MTB）感染患者发生小肠穿孔的病例，但迄今为止，尚无非结核分枝杆菌（NTM）感染导致肠穿孔的病例报道。