Vieira A R, Marazita M L, Goldstein-McHenry T
Department of Oral Biology, Universityof Pittsburgh School of Dental Medicine, Pittsburgh, PA 15261, USA.
J Dent Res. 2008 May;87(5):435-9. doi: 10.1177/154405910808700506.
Here we report the first genome-wide scan performed for caries. Evidence from twin studies suggests a genetic component to caries. We aimed to identify genetic factors contributing to caries in a population similarly influenced by confounding factors, such as diet, oral hygiene habits, fluoride exposure, and access to dental care. Forty-six families with similar cultural and behavioral habits, and living in the Philippines, were studied, and genome-wide genotype data and DMFT (Decayed, Missing due to caries, Filled Teeth) scores were evaluated. Suggestive loci logarithmic odds (LOD) scores above 2.0 or non-parametric p-values below 0.0009) were found for low caries susceptibility (5q13.3, 14q11.2, and Xq27.1) and high caries susceptibility (13q31.1 and 14q24.3). Genes that may be related to saliva flow and diet preferences are proposed as possible candidates. A protective locus for caries in the X chromosome may explain the gender differences seen in caries frequency.
在此，我们报告首次针对龋齿进行的全基因组扫描。双胞胎研究的证据表明龋齿存在遗传因素。我们旨在确定在受饮食、口腔卫生习惯、氟暴露和获得牙科护理等混杂因素影响相似的人群中导致龋齿的遗传因素。对居住在菲律宾、具有相似文化和行为习惯的46个家庭进行了研究，并评估了全基因组基因型数据和DMFT（龋失补牙数）得分。发现低龋齿易感性（5q13.3、14q11.2和Xq27.1）和高龋齿易感性（13q31.1和14q24.3）的暗示性基因座对数优势（LOD）得分高于2.0或非参数p值低于0.0009）。提出了可能与唾液流量和饮食偏好相关的基因作为可能的候选基因。X染色体上的一个龋齿保护基因座可能解释了龋齿发生率中观察到的性别差异。
