纤维蛋白原及纤维蛋白原基因β148和β854多态性与冠心病的关联
Association of fibrinogen and fibrinogen gene beta148 and beta854 polymorphisms with coronary heart disease.
作者信息
Sun Ai-jun, Ma Hui-li, Chen Xue-ying, Wang Ying, Fang Ye-ming, Ma Yong-li, Wang Ke-qiang, Zou Yun-zeng, Huang Wei, Ge Jun-bo
机构信息
Department of Cardiology, Zhongshan Hospital, Fudan University, Shanghai Institute of Cardiovascular Disease, Shanghai, China.
出版信息
Cardiology. 2008;111(3):167-70. doi: 10.1159/000121599. Epub 2008 Apr 25.
BACKGROUND
The aim of this study was to observe the association between fibrinogen C148T, G854A polymorphisms and plasma fibrinogen levels in a large cohort of Chinese patients with coronary heart disease (CHD).
METHODS
Fibrinogen gene beta148/beta854 polymorphisms were screened and plasma fibrinogen levels and lipids were measured in patients with angiographically confirmed CHD (n = 836) and in controls without CHD (n = 418).
RESULTS
Age, sex, smoking, hypertension, diabetes mellitus, blood lipids and fibrinogen levels were related to CHD (all p < 0. 05) while the frequencies of fibrinogen beta148 and beta854 alleles, gene and genotypes between the two groups were similar (all p > 0.05).
CONCLUSION
This study demonstrates that the plasma fibrinogen level, but not fibrinogen beta148 and beta854 genotypes, was associated with CHD in the Chinese population.
背景
本研究旨在观察中国一大群冠心病（CHD）患者中纤维蛋白原C148T、G854A基因多态性与血浆纤维蛋白原水平之间的关联。
方法
对经血管造影证实的冠心病患者（n = 836）和无冠心病的对照者（n = 418）进行纤维蛋白原基因beta148/beta854多态性筛查，并测量血浆纤维蛋白原水平和血脂。
结果
年龄、性别、吸烟、高血压、糖尿病、血脂和纤维蛋白原水平与冠心病相关（所有p < 0.05），而两组之间纤维蛋白原beta148和beta854等位基因、基因及基因型的频率相似（所有p > 0.05）。
结论
本研究表明，在中国人群中，血浆纤维蛋白原水平而非纤维蛋白原beta148和beta854基因型与冠心病相关。
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