Borsari V, Fini M, Giavaresi G, Tschon M, Chiesa R, Chiusoli L, Salito A, Rimondini L, Giardino R
Laboratory of Experimental Surgery, Research Institute Codivilla-Putti, Rizzoli Orthopaedic Institute, Bologna, Italy.
J Biomed Mater Res A. 2009 May;89(2):550-60. doi: 10.1002/jbm.a.31995.
Ti (PG60) and Ti plus HA (HPG60) dense coatings with ultrahigh roughness (Ra: 74 +/- 8 microm and 53 +/- 18 microm, respectively) were compared to high Ti (Ti60) and Ti plus HA (HT60) high roughened porous coatings (Ra: 40 +/- 7 microm and 36 +/- 3 microm, respectively). Surfaces were implanted in cortical and trabecular bone of young adult (YOUNG), aged (AGED) and estrogen-deficient sheep (OVX) and analyzed by means of histology, histomorphometry and push-out tests 3 months after implantation. A significantly lower value in affinity index (AI) of PG60 when compared to TI60 (p < 0.01) was observed in cortical bone. In trabecular bone, lower values in AI were found in TI60 and PG60 when compared to their HA-coated surfaces (p < 0.0005). Bone ingrowth (BI) of TI60 and PG60 was significantly lower than that of the HA-coated surfaces in trabecular bone (p < 0.05). Significantly lower values in BI in OVX sheep in comparison to YOUNG sheep in both cortical and trabecular bone were observed (p < 0.05). Data showed that high roughness and Ti and HA-coated surfaces are suitable for aged and osteoporotic patients. HA coatings represent the most successful strategy in trabecular bone.
将具有超高粗糙度（分别为Ra：74±8微米和53±18微米）的钛（PG60）涂层及钛加羟基磷灰石（HPG60）涂层与高钛（Ti60）和钛加羟基磷灰石（HT60）的高粗糙度多孔涂层（分别为Ra：40±7微米和36±3微米）进行比较。将这些表面植入年轻成年（YOUNG）、老年（AGED）和雌激素缺乏绵羊（OVX）的皮质骨和松质骨中，并在植入3个月后通过组织学、组织形态计量学和推出试验进行分析。在皮质骨中，观察到PG60的亲和指数（AI）值与TI60相比显著更低（p<0.01）。在松质骨中，与它们的羟基磷灰石涂层表面相比，TI60和PG60的AI值更低（p<0.0005）。在松质骨中，TI60和PG60的骨长入（BI）显著低于羟基磷灰石涂层表面（p<0.05）。在皮质骨和松质骨中，与年轻绵羊相比，OVX绵羊的BI值显著更低（p<0.05）。数据表明，高粗糙度以及钛和羟基磷灰石涂层表面适用于老年和骨质疏松患者。羟基磷灰石涂层是松质骨中最成功的策略。
