Byard R W, Burrows P E, Izakawa T, Silver M M
Department of Pathology, Hospital for Sick Children, University of Toronto, Ontario, Canada.
Eur J Pediatr. 1991 Feb;150(4):224-7. doi: 10.1007/BF01955516.
The clinicopathological features of five fatal cases of diffuse haemangiomatosis presenting in neonatal life or early infancy are presented. The infants all had multiple skin haemangiomas as well as deep-seated lesions in many different tissues that caused protean clinical manifestations and management problems. Because the outlook may be improved by early diagnosis and application of new modes of treatment, any infant with multiple cutaneous haemangiomas should be closely assessed for possible visceral involvement. Development of hepatomegaly, high-output cardiac failure, unexplained anaemia or thrombocytopenia in these infants should immediately suggest disseminated disease. Early recognition with implementation of steroid and/or antiangiogenic therapy, embolization and/or surgery is essential to improve the chances of survival.
本文介绍了5例在新生儿期或婴儿早期出现的弥漫性血管瘤病致死病例的临床病理特征。这些婴儿均有多发皮肤血管瘤以及许多不同组织中的深部病变，导致了多种多样的临床表现和治疗问题。由于早期诊断和应用新的治疗模式可能改善预后，任何患有多发皮肤血管瘤的婴儿都应接受密切评估，以确定是否可能存在内脏受累。这些婴儿出现肝肿大、高输出量心力衰竭、不明原因的贫血或血小板减少应立即提示疾病播散。早期识别并实施类固醇和/或抗血管生成治疗、栓塞和/或手术对于提高生存几率至关重要。
