吉氏柠檬酸杆菌O9a、9b去乙酰化O-PS1的含间隔基二糖、三糖和四糖片段以及一种相关五糖的合成。
Synthesis of spacer-equipped di-, tri-, and the tetrasaccharide fragments of the deacetylated O-PS1 of Citrobacter gillenii O9a,9b, and a related pentasaccharide.
作者信息
Saksena Rina, Chernyak Anatoli, Kovác Pavol
机构信息
NIDDK, LBC, National Institutes of Health, Bethesda, MD 20892-0815, USA.
出版信息
Carbohydr Res. 2008 Jul 21;343(10-11):1693-706. doi: 10.1016/j.carres.2008.03.037. Epub 2008 Apr 4.
Abstract
The title rhamnooligosaccharides [alpha-D-Rhap4NAc-(1-->3)-alpha-D-Rhap4NAc-1-O-(CH(2))(5)COOMe, alpha-D-Rhap4NAc-(1-->3)-alpha-D-Rhap4NAc-(1-->3)-alpha-D-Rhap4NAc-1-O-(CH(2))(5)COOMe, alpha-D-Rhap4NAc-(1-->2)-alpha-D-Rhap4NAc-(1-->3)-alpha-D-Rhap4NAc-(1-->3)-alpha-D-Rhap4NAc-1-O-(CH(2))(5)COOMe, and alpha-D-Rhap4NAc-(1-->3)-alpha-D-Rhap4NAc-(1-->2)-alpha-D-Rhap4NAc-(1-->3)-alpha-D-Rhap4NAc-(1-->3)-alpha-D-Rhap4NAc-1-O-(CH(2))(5)COOMe] were synthesized in a stepwise fashion from 5-methoxycarbonylpentyl 4-azido-4,6-dideoxy-2-O-benzyl-alpha-D-mannopyranoside and orthogonally protected 1-thioglycoside glycosyl donors. The amorphous, final products were fully characterized as corresponding per-O-acetyl derivatives.
摘要
鼠李糖低聚糖[α-D-鼠李糖-4-乙酰氨基-(1→3)-α-D-鼠李糖-4-乙酰氨基-1-O-(CH₂)₅COOMe、α-D-鼠李糖-4-乙酰氨基-(1→3)-α-D-鼠李糖-4-乙酰氨基-(1→3)-α-D-鼠李糖-4-乙酰氨基-1-O-(CH₂)₅COOMe、α-D-鼠李糖-4-乙酰氨基-(1→2)-α-D-鼠李糖-4-乙酰氨基-(1→3)-α-D-鼠李糖-4-乙酰氨基-(1→3)-α-D-鼠李糖-4-乙酰氨基-1-O-(CH₂)₅COOMe以及α-D-鼠李糖-4-乙酰氨基-(1→3)-α-D-鼠李糖-4-乙酰氨基-(1→2)-α-D-鼠李糖-4-乙酰氨基-(1→3)-α-D-鼠李糖-4-乙酰氨基-(1→3)-α-D-鼠李糖-4-乙酰氨基-1-O-(CH₂)₅COOMe]由5-甲氧基羰基戊基4-叠氮基-4,6-二脱氧-2-O-苄基-α-D-甘露吡喃糖苷和正交保护的1-硫代糖苷糖基供体逐步合成。无定形的最终产物被完全表征为相应的全-O-乙酰基衍生物。
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One-pot preparation of a series of glycoconjugates with predetermined antigen-carrier ratio from oligosaccharides that mimic the O-PS of Vibrio cholerae O:1, serotype Ogawa.从模拟霍乱弧菌O:1小川血清型O-PS的寡糖一锅法制备一系列具有预定抗原-载体比例的糖缀合物。
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Structures of two O-chain polysaccharides of Citrobacter gillenii O9a,9b lipopolysaccharide. A new homopolymer of 4-amino-4,6-dideoxy-D-mannose (perosamine).吉氏柠檬酸杆菌O9a,9b脂多糖的两种O-链多糖结构。一种新的4-氨基-4,6-二脱氧-D-甘露糖（perosamine）均聚物。
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Citrobacter freundii invades and replicates in human brain microvascular endothelial cells.弗氏柠檬酸杆菌可侵入人脑血管内皮细胞并在其中复制。
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Synthesis of methyl alpha-glycosides of some higher oligosaccharide fragments of the O-antigen of Vibrio cholerae O1, serotype Inaba and Ogawa.霍乱弧菌O1群稻叶型和小川型O抗原一些较高寡糖片段的α-甲基糖苷的合成。
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Synthesis of eight glycosides of hexasaccharide fragments representing the terminus of the O-polysaccharide of Vibrio cholerae O:1, serotype Inaba and Ogawa, bearing aglycons suitable for linking to proteins.合成了八种六糖片段的糖苷，这些六糖片段代表霍乱弧菌O:1、稻叶型和小川型血清型O-多糖的末端，并带有适合与蛋白质连接的糖苷配基。
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Synthesis of four glycosides of a disaccharide fragment representing the terminus of the O-polysaccharide of Vibrio cholerae O:1, serotype Inaba, bearing aglycons suitable for linking to proteins.霍乱弧菌O:1稻叶型O-多糖末端二糖片段的四种糖苷的合成，其糖苷配基适合与蛋白质连接。
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