Inoue Teruo, Eguchi Yutaka, Matsumoto Tetsuya, Kijima Yoshiyuki, Kato Yoji, Ozaki Yukio, Waseda Katsuhisa, Oda Hiroshi, Seiki Kosuke, Node Koichi, Urade Yoshihiro
Department of Cardiovascular and Renal Medicine, Saga University Faculty of Medicine, Saga, Japan.
Atherosclerosis. 2008 Dec;201(2):385-91. doi: 10.1016/j.atherosclerosis.2008.03.010. Epub 2008 Mar 16.
Lipocalin-type prostaglandin D synthase (L-PGDS), which is responsible for the biosynthesis of prostaglandin (PG) D(2), has been found to be present in the atherosclerotic plaque of the human coronary artery and also to be detectable in human serum. This multicenter cooperative study was designed to establish the diagnostic value of measuring serum L-PGDS for coronary artery disease. The study included 1013 consecutive patients suspected of having stable coronary artery disease who underwent diagnostic coronary angiography. Peripheral blood was collected prior to angiography. The serum level of L-PGDS, as determined by a sandwich ELISA, was 58.1 +/- 2.2, 62.0 +/- 1.8 and 80.6 +/- 2.6 microg/dl for patients with no stenotic lesion (N, n=241), single-vessel coronary artery disease (S, n=351), and multi-vessel coronary artery disease (M, n=421), respectively (N vs. S; P<0.001, S vs. M; P<0.01, N vs. M; P<0.001). Multiple regression analysis indicated that the most powerful independent predictor of the coronary severity score (Gensini Score) was the L-PGDS level (R=0.55, P<0.0001). The serum L-PGDS level is suitable to evaluate the severity of coronary artery disease. The measurement of serum L-PGDS can be a strategy for screening of stable coronary artery disease prior to coronary angiography.
脂联素型前列腺素D合成酶（L-PGDS）负责前列腺素（PG）D2的生物合成，已发现其存在于人类冠状动脉的动脉粥样硬化斑块中，并且在人血清中也可检测到。这项多中心合作研究旨在确定检测血清L-PGDS对冠状动脉疾病的诊断价值。该研究纳入了1013例连续怀疑患有稳定型冠状动脉疾病并接受诊断性冠状动脉造影的患者。在血管造影术前采集外周血。通过夹心ELISA测定，无狭窄病变患者（N组，n = 241）、单支冠状动脉疾病患者（S组，n = 351）和多支冠状动脉疾病患者（M组，n = 421）的血清L-PGDS水平分别为58.1±2.2 μg/dl、62.0±1.8 μg/dl和80.6±2.6 μg/dl（N组与S组比较，P<0.001；S组与M组比较，P<0.01；N组与M组比较，P<0.001）。多元回归分析表明，冠状动脉严重程度评分（Gensini评分）最有力的独立预测指标是L-PGDS水平（R = 0.55，P<0.0001）。血清L-PGDS水平适用于评估冠状动脉疾病的严重程度。检测血清L-PGDS可作为冠状动脉造影术前筛查稳定型冠状动脉疾病的一种策略。
