Woodley John M
Center for BioProcess Engineering, Department of Chemical and Biochemical Engineering, Technical University of Denmark, DK-2800 Lyngby, Denmark.
Trends Biotechnol. 2008 Jun;26(6):321-7. doi: 10.1016/j.tibtech.2008.03.004. Epub 2008 Apr 22.
The pharmaceutical industry requires synthetic routes to be environmentally compatible as well as to fulfill the demands of process economics and product specification and to continually reduce development times. Biocatalysis has the potential to deliver 'greener' chemical syntheses, and in this review some of these opportunities are outlined and outstanding challenges presented. Future development will require research targeted towards increased commercial availability of key enzymes, as well as the improvement of enzyme stability and substrate repertoire, to fully realize the potential of biocatalysis for making pharmaceutical processes greener.
制药行业要求合成路线既要与环境兼容，又要满足过程经济性和产品规格的要求，并不断缩短开发时间。生物催化有潜力实现“更绿色”的化学合成，在本综述中概述了其中的一些机会，并提出了突出的挑战。未来的发展将需要针对提高关键酶的商业可得性以及改善酶的稳定性和底物范围进行研究，以充分实现生物催化使制药过程更绿色的潜力。
