Robert Frederick Smith School of Chemical and Biomolecular Engineering, Cornell University, Ithaca, New York, USA; email:
Annu Rev Anal Chem (Palo Alto Calif). 2024 Jul;17(1):339-366. doi: 10.1146/annurev-anchem-061622-042618.
Nature has inspired the development of biomimetic membrane sensors in which the functionalities of biological molecules, such as proteins and lipids, are harnessed for sensing applications. This review provides an overview of the recent developments for biomembrane sensors compatible with either bulk or planar sensing applications, namely using lipid vesicles or supported lipid bilayers, respectively. We first describe the individual components required for these sensing platforms and the design principles that are considered when constructing them, and we segue into recent applications being implemented across multiple fields. Our goal for this review is to illustrate the versatility of nature's biomembrane toolbox and simultaneously highlight how biosensor platforms can be enhanced by harnessing it.
自然启发了仿生膜传感器的发展，在这些传感器中，生物分子（如蛋白质和脂质）的功能被用于传感应用。本综述概述了与体相或平面传感应用兼容的生物膜传感器的最新进展，分别使用脂质体或支撑脂质双层。我们首先描述了这些传感平台所需的各个组件以及构建它们时考虑的设计原则，并逐步介绍了正在多个领域实施的最新应用。我们撰写这篇综述的目的是说明自然界生物膜工具箱的多功能性，同时强调如何通过利用它来增强生物传感器平台。
