白细胞介素-10基因多态性与酒精中毒有关，但与酒精性肝病无关。
Interleukin-10 gene polymorphism is associated with alcoholism but not with alcoholic liver disease.
作者信息
Marcos Miguel, Pastor Isabel, González-Sarmiento Rogelio, Laso Francisco Javier
机构信息
Servicio de Medicina Interna II, Hospital Universitario de Salamanca, Paseo de San Vicente 58-182, 37007 Salamanca, Spain.
出版信息
Alcohol Alcohol. 2008 Sep-Oct;43(5):523-8. doi: 10.1093/alcalc/agn026. Epub 2008 Apr 24.
AIMS
To determine whether the functional polymorphism -592C>A of the interleukin (IL)-10 gene (IL10) influences the development of alcoholic liver disease or alcoholism in alcoholic Spanish subjects.
METHODS
The -592C>A IL10 polymorphism was analyzed by the polymerase chain reaction and digestion with restriction enzymes in 257 male alcoholics [161 without alcoholic liver disease and 96 with alcoholic liver cirrhosis (ALC)] and 100 male healthy controls.
RESULTS
We found no association between the -592C>A IL10 polymorphism and ALC. Meta-analysis combining this result and data from previous studies failed also to show any significant association between this polymorphism and alcoholic liver disease. However, the frequency of allele A carriers (CA and AA genotypes) was significantly higher in alcoholic patients (defined as patients with abuse or dependence of alcohol) than in healthy controls.
CONCLUSION
The -592C>A IL10 polymorphism is not related to the risk of ALC. Nevertheless, our study shows that alcoholism is associated with an excess of allele A carriers in alcoholic patients.
目的
确定白细胞介素（IL）-10基因（IL10）的功能性多态性-592C>A是否影响西班牙酗酒者酒精性肝病或酒精中毒的发生。
方法
采用聚合酶链反应和限制性酶切分析257名男性酗酒者[161名无酒精性肝病者和96名酒精性肝硬化（ALC）者]及100名男性健康对照者的-592C>A IL10多态性。
结果
我们发现-592C>A IL10多态性与ALC之间无关联。将本结果与既往研究数据进行荟萃分析，也未显示该多态性与酒精性肝病之间存在任何显著关联。然而，酗酒患者（定义为有酒精滥用或依赖的患者）中A等位基因携带者（CA和AA基因型）的频率显著高于健康对照者。
结论
-592C>A IL10多态性与ALC风险无关。尽管如此，我们的研究表明酒精中毒与酗酒患者中A等位基因携带者过多有关。
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