[异种移植冲突。术前全身淋巴照射的作用]

[Conflicting xenograft. Role of preoperative total lymphoid irradiation].

作者信息

Tixier D, Levy C, Le Bourgeois J P, Leandri J, Loisance D

机构信息

Centre de Recherches chirurgicales, C.N.R.S. URA 1431 (Pr Loisance), Université Paris XIII, Créteil.

出版信息

Chirurgie. 1991;117(9):717-25.

PMID:1843672

Abstract

This study deals with an experimental model of discordant cardiac xenograft between 24 donor lambs of the Préalpes race and 24 recipient Camborough pigs divided up into 4 groups: I control (6) without immunosuppressive treatment; II (5) with pharmacological immunosuppression (IP); III (13) with PI and total lymphoid irradiation (TLI) and immediate graft, divided up into IIIa (5) with high-rate (HR) TLI and IIIb with low-rate (LR) TLI; IV (4) with a two-week lapse between TLI and grafting. The best graft survival rate (GSR) is obtained either after delayed LR-TLI or after LR-TLI without delay. This study seems to be the first one demonstrating that for discordant xenogenic grafts, TLI associated to PI with cyclosporin A (Cy A) significantly prolongs the survival of the graft (30 times).

摘要

本研究涉及普雷阿尔普斯品种的24只供体羔羊与24只受体坎伯罗猪之间的异种心脏移植实验模型，分为4组：I组为对照组（6只），不进行免疫抑制治疗；II组（5只）采用药物免疫抑制（IP）；III组（13只）采用PI和全身淋巴照射（TLI）并立即进行移植，分为IIIa组（5只）采用高剂量率（HR）TLI和IIIb组采用低剂量率（LR）TLI；IV组（4只）在TLI和移植之间间隔两周。延迟LR-TLI后或无延迟的LR-TLI后可获得最佳移植物存活率（GSR）。本研究似乎是第一项表明，对于异种移植，TLI联合PI及环孢素A（Cy A）可显著延长移植物存活时间（30倍）的研究。