Zhang Xiaoyu
Department of Plant Biology, University of Georgia, Athens, GA 30602, USA.
Science. 2008 Apr 25;320(5875):489-92. doi: 10.1126/science.1153996.
In plants, DNA methylation, histone modifications, and RNA interference play critically important roles in regulating chromatin structure, thereby profoundly affecting transcription and other molecular events. Recent advances in microarray and high-throughput sequencing technologies have enabled genome-wide studies of these pathways in great detail. The vast amounts of "epigenomic" data generated so far have provided new insights into the mechanisms and functions of these pathways and have broadened our understanding of the structure and organization of plant chromatin as a whole.
在植物中,DNA甲基化、组蛋白修饰和RNA干扰在调节染色质结构方面发挥着至关重要的作用,从而深刻影响转录和其他分子事件。微阵列和高通量测序技术的最新进展使得能够对这些途径进行全基因组的详细研究。迄今为止产生的大量“表观基因组”数据为这些途径的机制和功能提供了新的见解,并拓宽了我们对植物染色质整体结构和组织的理解。