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植物中的表观遗传继承

Epigenetic inheritance in plants.

作者信息

Henderson Ian R, Jacobsen Steven E

机构信息

Department of Molecular, Cell and Developmental Biology, Howard Hughes Medical Institute, University of California, Los Angeles, California 90095, USA.

出版信息

Nature. 2007 May 24;447(7143):418-24. doi: 10.1038/nature05917.

Abstract

The function of plant genomes depends on chromatin marks such as the methylation of DNA and the post-translational modification of histones. Techniques for studying model plants such as Arabidopsis thaliana have enabled researchers to begin to uncover the pathways that establish and maintain chromatin modifications, and genomic studies are allowing the mapping of modifications such as DNA methylation on a genome-wide scale. Small RNAs seem to be important in determining the distribution of chromatin modifications, and RNA might also underlie the complex epigenetic interactions that occur between homologous sequences. Plants use these epigenetic silencing mechanisms extensively to control development and parent-of-origin imprinted gene expression.

摘要

植物基因组的功能取决于染色质标记,如DNA甲基化和组蛋白的翻译后修饰。对拟南芥等模式植物的研究技术使研究人员能够开始揭示建立和维持染色质修饰的途径,而基因组研究则能在全基因组范围内绘制DNA甲基化等修饰图谱。小RNA似乎在决定染色质修饰的分布中起重要作用,RNA也可能是同源序列之间复杂表观遗传相互作用的基础。植物广泛利用这些表观遗传沉默机制来控制发育和印记基因的亲本来源表达。

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