Fasshauer Mathias, Seeger Jeannette, Waldeyer Theresa, Schrey Susanne, Ebert Thomas, Kratzsch Jürgen, Lössner Ulrike, Blüher Matthias, Stumvoll Michael, Faber Renaldo, Stepan Holger
Department of Internal Medicine III, University of Leipzig, Leipzig, Germany.
Am J Hypertens. 2008 May;21(5):582-6. doi: 10.1038/ajh.2008.23. Epub 2008 Mar 13.
Preeclampsia (PE) is a serious complication of pregnancy which is associated with an increased future metabolic and cardiovascular risk for both mother and newborn. Recently, adipocyte fatty acid-binding protein (AFABP) was introduced as a novel adipokine, serum levels of which independently correlate with the development of the metabolic syndrome and cardiovascular disease in humans. In this study, we investigated serum concentrations of the adipokine AFABP in patients with PE as compared to healthy controls of similar gestational age.
AFABP serum levels were quantified by enzyme-linked immunosorbent assay (ELISA) in control (n = 20) and PE (n = 16) patients. Furthermore, AFABP was correlated to clinical and biochemical measures of renal function, glucose, and lipid metabolism, as well as inflammation.
Mean maternal AFABP concentrations were significantly elevated in PE (24.5 +/- 9.7 microg/l) as compared to controls (14.8 +/- 7.1 microg/l). Furthermore, AFABP serum levels correlated positively with age, body mass index (BMI), blood pressure, serum creatinine, free fatty acids (FFAs), leptin, and C-reactive protein (CRP). In multivariate analyses, BMI and serum creatinine remained independently associated with AFABP concentrations and explained 58% of the variation in AFABP levels.
We demonstrate that maternal AFABP serum concentrations are significantly increased in PE. Furthermore, BMI and serum creatinine are independent predictors of circulating AFABP.
子痫前期（PE）是一种严重的妊娠并发症，与母亲和新生儿未来代谢及心血管疾病风险增加相关。最近，脂肪细胞脂肪酸结合蛋白（AFABP）作为一种新型脂肪因子被提出，其血清水平与人类代谢综合征和心血管疾病的发生独立相关。在本研究中，我们调查了与相似孕周的健康对照相比，PE患者血清中脂肪因子AFABP的浓度。
通过酶联免疫吸附测定（ELISA）对对照组（n = 20）和PE组（n = 16）患者的AFABP血清水平进行定量。此外，将AFABP与肾功能、血糖、脂质代谢以及炎症的临床和生化指标进行关联分析。
与对照组（14.8±7.1μg/l）相比，PE组孕妇的平均AFABP浓度显著升高（24.5±9.7μg/l）。此外，AFABP血清水平与年龄、体重指数（BMI）、血压、血清肌酐、游离脂肪酸（FFA）、瘦素和C反应蛋白（CRP）呈正相关。在多变量分析中，BMI和血清肌酐仍与AFABP浓度独立相关，并解释了AFABP水平变化的58%。
我们证明PE患者孕妇血清中AFABP浓度显著升高。此外，BMI和血清肌酐是循环AFABP的独立预测因素。
