初步报告：子痫前期患者血清视黄醇结合蛋白4水平

Preliminary report: Serum levels of retinol-binding protein 4 in preeclampsia.

作者信息

Stepan Holger, Ebert Thomas, Schrey Susanne, Reisenbüchler Constanze, Blüher Matthias, Stumvoll Michael, Kratzsch Jürgen, Tönnessen Patricia, Faber Renaldo, Fasshauer Mathias

机构信息

Department of Obstetrics, University of Leipzig, Leipzig 04103, Germany.

出版信息

Metabolism. 2009 Mar;58(3):275-7. doi: 10.1016/j.metabol.2008.10.001.

DOI:10.1016/j.metabol.2008.10.001

PMID:19217438

Abstract

The objective of the study was to investigate serum levels of the adipokine retinol-binding protein 4 (RBP4) in patients with preeclampsia (PE) as compared with healthy controls of similar gestational age. Retinol-binding protein 4 serum levels were quantified by enzyme-linked immunosorbent assay in control (n = 20) and PE (n = 16) patients. Mean maternal RBP4 concentrations were not significantly different in PE (24.5 mg/L) as compared with controls (22.3 mg/L). Furthermore, RBP4 did not correlate to clinical and biochemical measures of pregnancy outcome, renal function, glucose, and lipid metabolism, as well as inflammation. Our results do not support a role of RBP4 in the pathogenesis of PE.

摘要

本研究的目的是调查子痫前期（PE）患者与孕周相似的健康对照者相比，血清中脂肪因子视黄醇结合蛋白4（RBP4）的水平。通过酶联免疫吸附测定法对20例对照患者和16例PE患者的血清视黄醇结合蛋白4水平进行定量。与对照组（22.3mg/L）相比，PE患者的母体RBP4平均浓度（24.5mg/L）无显著差异。此外，RBP4与妊娠结局、肾功能、葡萄糖和脂质代谢以及炎症的临床和生化指标均无相关性。我们的结果不支持RBP4在PE发病机制中起作用。