Akbal Cem, Tanidir Yilören, Ozgen Mahir Bülent, Simşek Ferruh
Department of Urology, Marmara University School of Medicine, Tophanelioğlu Cad. No: 13-15, Altunizade, Istanbul, 34662, Turkey.
Int Urol Nephrol. 2008;40(4):971-5. doi: 10.1007/s11255-008-9381-4. Epub 2008 Apr 24.
The aim of this study is to determine the sexual dysfunction in patient with retroperitoneal fibrosis (RPF) and also we explored probability of Peyronie's disease (PD) in this patient group and to compare this with the controls.
Ten of 17 male RPF patients formed the basis of this study. Patient's age, concomitant diseases were recorded. The diagnosis of PD was based on a palpable penile plaque or acquired penile curvature. Age-matched 88 patients who were admitted to our outpatient clinic with elevated PSA level served as the control group. All patients were asked to complete the IIEF-5 questionnaire. The severity of the erectile dysfunction (ED) was classified into four categories: severe (5-7), moderate (8-16), mild (17-21), and no ED (22-25). Concomitant systemic diseases were recorded. Statistical analyses were done by the Fisher's exact test and an unpaired-sample t-test.
Patients with severe ED or no sexual intercourse in the study group and the control group during the study period were found to be 7 and 14, respectively. The median IIEF-5 score in RPF patients and the control group was 9.8 (min: 5 to max: 23) and 19 (min: 5 to max: 25), respectively. The differences between groups were statistically significant (P = 0.002). In particular, ED was reported in eight RPF patients (80%) which was severe in six (60%) and moderate in two (20%). ED was reported in 45 patients in the control group (51%) which was severe in 14 (15.9%), mild in 25 (28.4%), and moderate in six (6.8%). Patients with RPF had a significant tendency for severe ED compared with the control group (P = 0.0042). Two patients in the RPF group (20%) and one patient in the control group (1.1%) were found to have a penile plaque (P = 0.0279). Relative risk for developing a penile plague was found to be 0.8 in RPF.
RPF patients are found to be more prone to developing ED. Penile plaque formation was identified in RPF patients, which may be presumed to relate to the pathological changes of the RPF process, but it remains unclear that these patients demonstrate a higher incidence of plaque formation than the normal population.
本研究旨在确定腹膜后纤维化（RPF）患者的性功能障碍情况，同时探讨该患者群体中佩罗尼氏病（PD）的发生概率，并与对照组进行比较。
17例男性RPF患者中的10例构成了本研究的基础。记录患者的年龄、伴随疾病。PD的诊断基于可触及的阴茎硬结或后天性阴茎弯曲。88例年龄匹配、因前列腺特异性抗原（PSA）水平升高而入住我院门诊的患者作为对照组。所有患者均被要求完成国际勃起功能指数-5（IIEF-5）问卷。勃起功能障碍（ED）的严重程度分为四类：重度（5 - 7分）、中度（8 - 16分）、轻度（17 - 21分）和无ED（22 - 25分）。记录伴随的全身性疾病。采用Fisher精确检验和非配对样本t检验进行统计分析。
研究组和对照组在研究期间重度ED或无性交的患者分别为7例和14例。RPF患者和对照组的IIEF-5评分中位数分别为9.8（最小值：5，最大值：23）和19（最小值：5，最大值：25）。两组间差异具有统计学意义（P = 0.002）。特别是，8例RPF患者（80%）报告有ED，其中6例（60%）为重度，2例（20%）为中度。对照组45例患者（51%）报告有ED，其中14例（15.9%）为重度，25例（28.4%）为轻度，6例（6.8%）为中度。与对照组相比，RPF患者发生重度ED的倾向显著（P = 0.0042）。RPF组有2例患者（20%）和对照组有1例患者（1.1%）被发现有阴茎硬结（P = 0.0279）。RPF患者发生阴茎硬结的相对风险为0.8。
发现RPF患者更容易发生ED。在RPF患者中发现了阴茎硬结形成，这可能被认为与RPF过程的病理变化有关，但尚不清楚这些患者的硬结形成发生率是否高于正常人群。
