[芦荟素对色素沉着皮肤等效模型中黑素细胞的影响]
[The effect of aloesin on melanocytes in the pigmented skin equivalent model].
作者信息
Yang Zhuang-qun, Wang Zheng-Hui, Zhang Tie-Liang, Tu Jun-Bo, Song Yong, Hu Xiao-Yi, Li Guo-Guang
机构信息
Department of Oral and Maxillofacial Plastic Surgery, Stomatological College, Xi'an Jiao Tong University, Xi'an 710004, China.
出版信息
Zhonghua Zheng Xing Wai Ke Za Zhi. 2008 Jan;24(1):50-3.
OBJECTIVE
To observe the effect of aloesin, tea polyphenols, arbutin on melanocytes in the pigmented skin equivalent model.
METHODS
First, we constructed the pigmented skin equivalent model in vitro. And then we detected the effect of aloesin, tea polyphenols and arbutin on the cells' shape, tyrosinase activity and formation of melanin in the constructed pigmented skin equivalent.
RESULTS
Three depigmenting agents showed an inhibition effect on the tyrosinase activity of melanocytes and reduced significantly melanin content in the pigmented skin equivalent model, in which the tea polyphenols had the strongest effect, and then was the aloesin. But the tea polyphenols showed the strongest toxicity, while the aloesin and arbutin had a much lower toxicity.
CONCLUSIONS
All the three depigmenting agents showed a concentration dependent suppression effect on the tyrosinase activity and formation of melanin, in which the tea polyphenols was the strongest effect( P <0.05). Aoesin has a good suppression effect on the tyrosinase activity and formation of melanin, but has a much lower toxicity, which could be used as a safe depigmenting agent.
目的
观察芦荟素、茶多酚、熊果苷对色素沉着皮肤等效模型中黑素细胞的影响。
方法
首先，体外构建色素沉着皮肤等效模型。然后检测芦荟素、茶多酚和熊果苷对构建的色素沉着皮肤等效模型中细胞形态、酪氨酸酶活性及黑色素形成的影响。
结果
三种脱色剂对黑素细胞的酪氨酸酶活性均有抑制作用，并显著降低色素沉着皮肤等效模型中的黑色素含量，其中茶多酚作用最强，其次是芦荟素。但茶多酚毒性最强，而芦荟素和熊果苷毒性较低。
结论
三种脱色剂对酪氨酸酶活性和黑色素形成均呈浓度依赖性抑制作用，其中茶多酚作用最强（P<0.05）。芦荟素对酪氨酸酶活性和黑色素形成有良好的抑制作用，但毒性较低，可作为一种安全的脱色剂。
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