Choi S, Lee S-K, Kim J-E, Chung M-H, Park Y-I
Department of Pharmacology, Seoul National University College of Medicine, Seoul, Korea.
Clin Exp Dermatol. 2002 Sep;27(6):513-5. doi: 10.1046/j.1365-2230.2002.01120.x.
Skin hyperpigmentation is caused by the overproduction of melanin pigment, which is synthesized by the action of tyrosinase. We recently reported that aloesin inhibits tyrosinase activity. The present study was undertaken to test the inhibitory effect of aloesin on pigmentation in human skin after UV radiation. Experimental subjects were UV-irradiated (210 mJ) on the inner forearm. UV-irradiated regions were assigned to four groups: vehicle control, aloesin treated, arbutin treated, and aloesin and arbutin treated. Aloesin and/or arbutin were administered four times a day for 15 days. Aloesin treatment suppressed pigmentation by 34%, arbutin by 43.5%, and the cotreatment by 63.3% compared with the control (n = 15; P < 0.05). Moreover, aloesin treatment showed pigmentation suppression in a dose-dependent manner (n = 7; P < 0.05). These results raise the possibility that aloesin may be used as an agent that inhibits melanin formation induced by UV radiation.
皮肤色素沉着过度是由黑色素生成过多引起的，黑色素是通过酪氨酸酶的作用合成的。我们最近报道芦荟素能抑制酪氨酸酶的活性。本研究旨在测试芦荟素对紫外线照射后人体皮肤色素沉着的抑制作用。实验对象的前臂内侧接受紫外线照射（210 mJ）。紫外线照射区域分为四组：赋形剂对照组、芦荟素处理组、熊果苷处理组以及芦荟素和熊果苷联合处理组。芦荟素和/或熊果苷每天给药4次，持续15天。与对照组相比（n = 15；P < 0.05），芦荟素处理使色素沉着抑制了34%，熊果苷使色素沉着抑制了43.5%，联合处理使色素沉着抑制了63.3%。此外，芦荟素处理呈剂量依赖性地抑制色素沉着（n = 7；P < 0.05）。这些结果增加了芦荟素可能用作抑制紫外线辐射诱导的黑色素形成的药物的可能性。
