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用于活细胞细胞质磷光染色的阳离子铱(III)配合物。

Cationic iridium(III) complexes for phosphorescence staining in the cytoplasm of living cells.

作者信息

Yu Mengxiao, Zhao Qiang, Shi Linxi, Li Fuyou, Zhou Zhiguo, Yang Hong, Yi Tao, Huang Chunhui

机构信息

Department of Chemistry & Laboratory of Advanced Materials, Fudan University, Shanghai, 200433, PR China.

出版信息

Chem Commun (Camb). 2008 May 14(18):2115-7. doi: 10.1039/b800939b. Epub 2008 Feb 27.

Abstract

Two cationic iridium(III) complexes with bright green and red emissions were demonstrated as phosphorescent dyes for living cell imaging. In particular, their exclusive staining in cytoplasm, low cytotoxicity and reduced photobleaching, as well as cell membrane permeability, make the two complexes promising candidates for the design of specific bioimaging agents.

摘要

两种分别发出亮绿色和红色荧光的阳离子铱(III)配合物被证明可作为用于活细胞成像的磷光染料。特别是,它们在细胞质中的特异性染色、低细胞毒性、减少的光漂白以及细胞膜通透性,使得这两种配合物成为设计特定生物成像剂的有前景的候选物。

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