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闪耀生物系统之光：用于生物成像和生物传感应用的发光过渡金属配合物。

Shining New Light on Biological Systems: Luminescent Transition Metal Complexes for Bioimaging and Biosensing Applications.

机构信息

Department of Chemistry, City University of Hong Kong, Tat Chee Avenue, Kowloon, Hong Kong, P. R. China.

Laboratory for Synthetic Chemistry and Chemical Biology Limited, Units 1503-1511, 15/F, Building 17W, Hong Kong Science Park, New Territories, Hong Kong, P. R. China.

出版信息

Chem Rev. 2024 Aug 14;124(15):8825-9014. doi: 10.1021/acs.chemrev.3c00629. Epub 2024 Jul 25.

DOI:10.1021/acs.chemrev.3c00629
PMID:39052606
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11328004/
Abstract

Luminescence imaging is a powerful and versatile technique for investigating cell physiology and pathology in living systems, making significant contributions to life science research and clinical diagnosis. In recent years, luminescent transition metal complexes have gained significant attention for diagnostic and therapeutic applications due to their unique photophysical and photochemical properties. In this Review, we provide a comprehensive overview of the recent development of luminescent transition metal complexes for bioimaging and biosensing applications, with a focus on transition metal centers with a d, d, and d electronic configuration. We elucidate the structure-property relationships of luminescent transition metal complexes, exploring how their structural characteristics can be manipulated to control their biological behavior such as cellular uptake, localization, biocompatibility, pharmacokinetics, and biodistribution. Furthermore, we introduce the various design strategies that leverage the interesting photophysical properties of luminescent transition metal complexes for a wide variety of biological applications, including autofluorescence-free imaging, multimodal imaging, organelle imaging, biological sensing, microenvironment monitoring, bioorthogonal labeling, bacterial imaging, and cell viability assessment. Finally, we provide insights into the challenges and perspectives of luminescent transition metal complexes for bioimaging and biosensing applications, as well as their use in disease diagnosis and treatment evaluation.

摘要

发光成像技术是一种强大而通用的技术，可用于研究活系统中的细胞生理学和病理学，为生命科学研究和临床诊断做出了重大贡献。近年来，由于具有独特的光物理和光化学性质，发光过渡金属配合物在诊断和治疗应用方面引起了人们的极大关注。在这篇综述中，我们全面概述了发光过渡金属配合物在生物成像和生物传感应用方面的最新发展，重点介绍了具有 d、d 和 d 电子构型的过渡金属中心。我们阐明了发光过渡金属配合物的结构-性质关系，探讨了如何操纵其结构特征来控制其生物学行为，如细胞摄取、定位、生物相容性、药代动力学和生物分布。此外，我们介绍了各种设计策略，利用发光过渡金属配合物有趣的光物理性质，实现了广泛的生物学应用，包括无自发荧光成像、多模态成像、细胞器成像、生物传感、微环境监测、生物正交标记、细菌成像和细胞活力评估。最后，我们深入探讨了发光过渡金属配合物在生物成像和生物传感应用中的挑战和前景，以及它们在疾病诊断和治疗评估中的应用。

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