van Herten Yvonne R J, van de Kamer Jeroen B, van Wieringen Niek, Pieters Bradley R, Bel Arjan
Department of Radiation Oncology, University of Amsterdam, The Netherlands.
Radiother Oncol. 2008 Jul;88(1):156-62. doi: 10.1016/j.radonc.2008.03.016. Epub 2008 Apr 23.
To investigate the dosimetric effect of prostate rotations and limited on-line corrections by couch rotations (<or=3 degrees ) for prostate, seminal vesicles and organs at risk.
For 5 patients IMRT plans were made, treating the prostate plus base of the seminal vesicles. Realistic and idealised dose distributions were considered, the latter demonstrating extreme effects for rotations and their corrections. Translation errors were assumed to be corrected on-line. For each patient 20 treatments with different rotation errors were simulated: 20 systematic errors were generated and 20 times 35 random deviations were superimposed to simulate day-to-day variations. Using a research module of PLATO-RTS treatments with rotation errors, with and without on-line corrections, were simulated.
The largest dosimetric effect of rotation errors and corrections was found for the seminal vesicles with idealised dose distribution: coverage improved from 92.6% (range 89.9-96.0%) to 95.9% (94.7-98.1%). The gain for the idealised prostate was less: 95.9% (94.4-97.0%) to 97.5% (95.5-98.4%). For the femoral heads the dose increase could be as large as 12.2% (6.2-19.3%).
On-line correction of rotations can improve target coverage slightly. For organs at risk at a large distance from the isocentre the result can be a significant increase in dose.
研究前列腺旋转以及通过治疗床旋转(≤3度)进行有限在线校正对前列腺、精囊及危及器官的剂量学影响。
为5名患者制定调强放疗计划,治疗前列腺加精囊底部。考虑了实际和理想化的剂量分布,后者展示了旋转及其校正的极端影响。假定平移误差可在线校正。为每名患者模拟20种不同旋转误差的治疗情况:生成20种系统误差,并叠加20次35种随机偏差以模拟日常变化。使用PLATO-RTS的一个研究模块模拟有旋转误差、有或无在线校正的治疗情况。
对于理想化剂量分布的精囊,发现旋转误差和校正的最大剂量学影响:覆盖度从92.6%(范围89.9 - 96.0%)提高到95.9%(94.7 - 98.1%)。理想化前列腺的增益较小:从95.9%(94.4 - 97.0%)提高到97.5%(95.5 - 98.4%)。对于股骨头,剂量增加可能高达12.2%(6.2 - 19.3%)。
旋转的在线校正可略微提高靶区覆盖度。对于距等中心较远的危及器官,结果可能是剂量显著增加。