Xue Xiaochang, Feng Guodong, Li Meng, Qin Xin, Wu Shouzhen, Zhang Cun, You Yanjie, Wang Weihua, Jiang Changli, Liu Yan, Zhu Wenhua, Ran Yonggang, Zhang Zhen, Yan Zhen, Han Wei, Zhang Yingqi
Biotechnology Center of The Fourth Military Medical University, 17 Changle West Road, 710032 Xi'an, People's Republic of China.
Vaccine. 2008 Jun 2;26(23):2873-81. doi: 10.1016/j.vaccine.2008.03.043. Epub 2008 Apr 7.
The B-lymphocyte stimulator (BLyS) is implicated in various pathophysiological processes. The overexpression of BLyS has been observed in some human diseases, including systemic lupus erythematosus, rheumatoid arthritis, Sjögren's syndrome, and multiple sclerosis. This feature suggests that BLyS may be a therapeutic target for some human autoimmune diseases. We developed a therapeutic vaccine by coupling a tetanus toxoid T-helper cell epitope with the C-terminal of BLyS (TT-BLyS). This vaccine can induce high titers of neutralizing antibodies against BLyS in an animal model; the antibody has markedly protective effects on experimental autoimmune encephalomyelitis in rats, which is induced by inoculation of spinal cord homogenate. Our data suggest that the BLyS autovaccine may be a useful candidate for the treatment of some autoimmune diseases associated with the production of BLyS.
B淋巴细胞刺激因子（BLyS）与多种病理生理过程有关。在一些人类疾病中，包括系统性红斑狼疮、类风湿性关节炎、干燥综合征和多发性硬化症，已观察到BLyS的过表达。这一特征表明，BLyS可能是某些人类自身免疫性疾病的治疗靶点。我们通过将破伤风类毒素T辅助细胞表位与BLyS的C末端偶联，开发了一种治疗性疫苗（TT-BLyS）。该疫苗可在动物模型中诱导产生高滴度的抗BLyS中和抗体；该抗体对大鼠实验性自身免疫性脑脊髓炎具有显著的保护作用，该疾病是通过接种脊髓匀浆诱导产生的。我们的数据表明，BLyS自身疫苗可能是治疗某些与BLyS产生相关的自身免疫性疾病的有用候选药物。
