Yang Zhu, Cao You-De, Hu Li-Na, Wang Zhi-Biao
Department of Obstetrics & Gynecology, Second Affiliated Hospital, Chongqing Medical University, Chongqing, People's Republic of China.
Fertil Steril. 2009 Jun;91(6):2338-43. doi: 10.1016/j.fertnstert.2008.03.017. Epub 2008 Apr 28.
To investigate the feasibility of laparoscopic high-intensity focused ultrasound (HIFU) ablation in the treatment of patients with uterine localized adenomyosis.
A prospective clinical trial.
University teaching hospital.
PATIENT(S): Seven patients with uterine localized adenomyosis.
INTERVENTION(S): Using a hand-held focused ultrasound transducer, the HIFU procedure was performed by the same gynecologist for the treatment of a targeted adenomyosis during the surgical procedure, followed by hysterectomy.
MAIN OUTCOME MEASURE(S): Feasibility and effectiveness of HIFU treatment of localized adenomyomas.
RESULT(S): Macroscopic and microscopic examinations showed that HIFU induced thermal ablation of a targeted adenomyosis in all patients. The treated adenomyosis presented typical characteristics of coagulation necrosis, and the margin between the treated and untreated regions was clear in 2,3,5-triphenyltetrazolium chloride staining. By using electronic microscopy and nicotinamide adenine dinucleotide-diaphorase stain, complete loss of cellular viability was identified in the treated tissue.
CONCLUSION(S): The HIFU treatment is feasible and effective in the treatment of patients with uterine localized adenomyosis. It may provide a promising laparoscopic treatment for localized adenomyosis.
探讨腹腔镜高强度聚焦超声（HIFU）消融治疗子宫局限性腺肌病患者的可行性。
一项前瞻性临床试验。
大学教学医院。
7例子宫局限性腺肌病患者。
在手术过程中，由同一位妇科医生使用手持式聚焦超声换能器对目标腺肌病进行HIFU治疗，随后进行子宫切除术。
HIFU治疗局限性腺肌瘤的可行性和有效性。
大体和显微镜检查显示，HIFU在所有患者中均诱导了目标腺肌病的热消融。经治疗的腺肌病呈现典型的凝固性坏死特征，在2,3,5-三苯基氯化四氮唑染色中，治疗区与未治疗区之间的边界清晰。通过电子显微镜和烟酰胺腺嘌呤二核苷酸黄递酶染色，在治疗组织中确定细胞活力完全丧失。
HIFU治疗子宫局限性腺肌病患者是可行且有效的。它可能为局限性腺肌病提供一种有前景的腹腔镜治疗方法。
