Boehler C N, Münte T F, Krebs R M, Heinze H-J, Schoenfeld M A, Hopf J-M
Leibniz-Institute for Neurobiology, 39118 Magdeburg, Germany.
Cereb Cortex. 2009 Jan;19(1):134-45. doi: 10.1093/cercor/bhn063. Epub 2008 Apr 24.
In the present study magnetoencephalographic recordings were performed to investigate the neural mechanisms underlying the stopping of manual responses. Subjects performed in a Stop-signal task in which Go-stimuli (S1), requiring a rapid motor response, were sometimes rapidly followed by a Stop-stimulus (S2) indicating to withhold the already initiated response to S1. Success of stopping strongly depended on the early perceptual processing of S1 and S2 reflected by the magnetic N1 component. Enhanced processing of S1 facilitated the execution of the movement, whereas enhanced processing of S2 favored its inhibition. This suggests that the processing resources for the subsequent stimuli are limited and need to be shared. This sharing of resources appeared to arise from adjustments made on a trial-by-trial basis, in that systematic reaction time prolongations on Go-trials following Stop-trials versus following Go-trials were accompanied by attenuated sensory processing to the Go-stimulus similar to that seen in successful versus unsuccessful stopping in Stop-trials.
在本研究中，进行了脑磁图记录，以探究手动反应停止背后的神经机制。受试者进行了停止信号任务，在该任务中，需要快速做出运动反应的启动刺激（S1）有时会迅速被停止刺激（S2）跟随，S2指示抑制对S1已经启动的反应。停止的成功强烈依赖于由磁N1成分反映的S1和S2的早期感知处理。S1处理的增强促进了运动的执行，而S2处理的增强有利于其抑制。这表明后续刺激的处理资源是有限的，需要共享。这种资源共享似乎源于逐次试验进行的调整，因为与停止试验后再进行启动试验相比，停止试验后再进行启动试验时，系统反应时间延长，同时对启动刺激的感觉处理减弱，这与停止试验中成功与不成功停止时的情况类似。
