Calder I C, Goss D E, Williams P J, Funder C C, Green C R, Ham K N, Tange J D
Pathology. 1976 Jan;8(1):1-6. doi: 10.3109/00313027609094418.
N-hydroxyphenacetin, a phenacetin metabolite, was fed to rats as a 0.05-0.5% dietary supplement. After 9 months, tumours of the liver were found in 36 of 64 animals. One animal also developed a renal tumour. No tumours were found in control animals. The findings implicate phenacetin as a carcinogen and suggest that N-hydroxyphenacetin may be the metabolite responsible.
N-羟基非那西丁是一种非那西丁的代谢产物，以0.05 - 0.5%的膳食补充剂形式喂给大鼠。9个月后，64只动物中有36只被发现患有肝脏肿瘤。还有一只动物患上了肾肿瘤。在对照动物中未发现肿瘤。这些发现表明非那西丁是一种致癌物，并提示N-羟基非那西丁可能是起作用的代谢产物。
