巴甫洛夫对小鼠目标导向行为的影响：线索-强化物关系的作用。
Pavlovian influences on goal-directed behavior in mice: the role of cue-reinforcer relations.
作者信息
Crombag Hans S, Galarce Ezequiel M, Holland Peter C
机构信息
Department of Psychological and Brain Sciences, The Johns Hopkins University, Baltimore, Maryland 21218, USA.
出版信息
Learn Mem. 2008 Apr 25;15(5):299-303. doi: 10.1101/lm.762508. Print 2008 May.
Abstract
Two experiments refined procedures to study Pavlovian influences on goal-directed behavior in mice and studied the effects of CS-US relations in Pavlovian-instrumental interactions. Independent groups of mice underwent Pavlovian training to associate either a 10-sec or 2-min auditory stimulus (CS) with reward. We next assessed the ability of the response-contingent CS presentations to reinforce novel instrumental responding (conditioned reinforcement; CRf) or the ability of noncontingent CS presentations to increase ongoing instrumental responding (Pavlovian-instrumental transfer; PIT). Whereas 10-sec training conditions produced strong CRf (and no PIT), 2-min training conditions produced robust PIT (but no CRf).
摘要
两项实验优化了研究巴甫洛夫条件反射对小鼠目标导向行为影响的程序，并研究了巴甫洛夫条件反射与工具性反应相互作用中条件刺激（CS）-非条件刺激（US）关系的影响。独立的小鼠组接受巴甫洛夫训练，将10秒或2分钟的听觉刺激（CS）与奖励联系起来。接下来，我们评估了与反应相关的CS呈现增强新的工具性反应（条件强化；CRf）的能力，或非相关CS呈现增加正在进行的工具性反应（巴甫洛夫条件反射-工具性反应转移；PIT）的能力。10秒的训练条件产生了强烈的CRf（且无PIT），而2分钟的训练条件产生了强烈的PIT（但无CRf）。
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