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[作为抗疟药物靶点的新通道和转运体]

[New channels and transporters as anti-malaria drug targets].

作者信息

Xu Tao, Zhu Huai-min

机构信息

Department of Parasitology, The Second Military Medical University, Shanghai 200433, China.

出版信息

Zhongguo Ji Sheng Chong Xue Yu Ji Sheng Chong Bing Za Zhi. 2007 Oct;25(5):419-21.

Abstract

In order to get more nutrition from outside the erythrocyte, new channels were induced by malaria parasite. These channels play an important role in physiology of the parasitized cell. They are of interest both as potential targets in their own right and as potential drug targeting routes capable of mediating the entry of cytotoxic drugs into the appropriate compartment of the infected cell. It is hoped that this new anti-malarial strategy will help to create a sustainable anti-malaria-drug-development portfolio for the treatment of malaria.

摘要

为了从红细胞外部获取更多营养,疟原虫诱导产生了新的通道。这些通道在被寄生细胞的生理学中发挥着重要作用。它们本身作为潜在靶点以及作为能够介导细胞毒性药物进入感染细胞适当区室的潜在药物靶向途径都备受关注。希望这种新的抗疟策略将有助于创建一个可持续的抗疟疾药物开发组合用于疟疾治疗。

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