Dai Xiao-dong, Qin Yuan-hua, Zhou Chang-hai, Zheng Li-li, Shao Wei-jun, Tao Lin, Cui Yu
Department of Parasitology, Dalian Medical University, Dalian 116023, China.
Zhongguo Ji Sheng Chong Xue Yu Ji Sheng Chong Bing Za Zhi. 2007 Oct;25(5):436-8.
SD rat model of PCP was established by subcutaneous injection with dexamethasone. The treatment groups received Fructus Psoralea (FP, 10.0 mg/kg), Brucea javanica (BJ, 1.2 mg/kg) and a mixture of the two Chinese herbs(FP 5mg/kg, BJ 0.6 mg/kg) respectively. By means of detecting the level of IL-2 in sera and NK cells in spleens, the effect of FP and BJ on the level of IL-2 and NK cells in rats with Pneumocystis carinii pneumonia (PCP) was observed, with SMZco treatment group (TMP 50 mg/kg, SMZ 250 mg/kg) and groups of infected and normal rats as controls. Compared with the infected group, the level of IL-2(526.1 +/- 5.5) pg/ml and NK cells (27.1% +/- 0.8%) significantly increased in the FP group (P < 0.01), followed by the FP/BJ combination group [(314.7 +/- 6.7) pg/ml, 22.9% +/- 0.9%) (P < 0.05)], and BJ group [(285.4 +/- 6.1) pg/ml, 20.7% +/- l.0%) (P < 0.05)]. Chinese herbs Fructus Psoralea and Brucea javanica show an immune regulatory action on the PCP rats.
通过皮下注射地塞米松建立大鼠卡氏肺孢子虫肺炎（PCP）模型。治疗组分别给予补骨脂（FP，10.0毫克/千克）、鸦胆子（BJ，1.2毫克/千克）以及两种中药的混合物（FP 5毫克/千克，BJ 0.6毫克/千克）。通过检测血清中白细胞介素-2（IL-2）水平和脾脏中自然杀伤细胞（NK细胞）水平，观察补骨脂和鸦胆子对卡氏肺孢子虫肺炎（PCP）大鼠IL-2水平和NK细胞水平的影响，以复方新诺明治疗组（甲氧苄啶50毫克/千克，磺胺甲恶唑250毫克/千克）以及感染组和正常大鼠组作为对照。与感染组相比，补骨脂组中IL-2水平（526.1±5.5）皮克/毫升和NK细胞水平（27.1%±0.8%）显著升高（P<0.01），其次是补骨脂/鸦胆子联合组[（314.7±6.7）皮克/毫升，22.9%±0.9%]（P<0.05），鸦胆子组[（285.4±6.1）皮克/毫升，20.7%±1.0%]（P<0.05）。中药补骨脂和鸦胆子对PCP大鼠具有免疫调节作用。
