Wang Z I, Dell'Osso L F
Daroff-Dell'Osso Ocular Motility Laboratory, Louis Stokes Cleveland Department of Veterans Affairs Medical Center, Case Western Reserve University, 10701 East Boulevard, Cleveland, OH 44106, USA.
Vision Res. 2008 Jun;48(12):1409-19. doi: 10.1016/j.visres.2008.03.007. Epub 2008 Apr 28.
Our purpose was to perform a systematic study of the post-four-muscle-tenotomy procedure changes in target acquisition time by comparing predictions from the behavioral ocular motor system (OMS) model and data from infantile nystagmus syndrome (INS) patients. We studied five INS patients who underwent only tenotomy at the enthesis and reattachment at the original insertion of each (previously unoperated) horizontal rectus muscle for their INS treatment. We measured their pre- and post-tenotomy target acquisition changes using data from infrared reflection and high-speed digital video. Three key aspects were calculated and analyzed: the saccadic latency (Ls), the time to target acquisition after the target jump (Lt) and the normalized stimulus time within the cycle. Analyses were performed in MATLAB environment (The MathWorks, Natick, MA) using OMLAB software (OMtools, available from http://www.omlab.org). Model simulations were performed in MATLAB Simulink environment. The model simulation suggested an Lt reduction due to an overall foveation-quality improvement. Consistent with that prediction, improvement in Lt, ranging from approximately 200 ms to approximately 500 ms (average approximately 280 ms), was documented in all five patients post-tenotomy. The Lt improvement was not a result of a reduced Ls. INS patients acquired step-target stimuli faster post-tenotomy. This target acquisition improvement may be due to the elevated foveation quality resulting in less inherent variation in the input to the OMS. A refined behavioral OMS model, with "fast" and "slow" motor neuron pathways and a more physiological plant, successfully predicted this improved visual behavior and again demonstrated its utility in guiding ocular motor research.
我们的目的是通过比较行为性眼动系统（OMS）模型的预测结果和婴儿型眼球震颤综合征（INS）患者的数据，对四肌切断术后目标获取时间的变化进行系统研究。我们研究了5例INS患者，他们仅接受了肌腱附着处切断术，并将每只（之前未手术的）水平直肌重新附着于原附着点以治疗INS。我们使用红外反射和高速数字视频数据测量了他们切断术前和术后的目标获取变化。计算并分析了三个关键方面：扫视潜伏期（Ls）、目标跳跃后目标获取时间（Lt）以及周期内的标准化刺激时间。分析在MATLAB环境（MathWorks公司，马萨诸塞州纳蒂克）中使用OMLAB软件（可从http://www.omlab.org获取的OMtools）进行。模型模拟在MATLAB Simulink环境中进行。模型模拟表明，由于整体注视质量的提高，Lt有所降低。与该预测一致，所有5例患者在切断术后Lt均有改善，改善范围从约200毫秒至约500毫秒（平均约280毫秒）。Lt的改善并非Ls降低的结果。INS患者在切断术后获取阶跃目标刺激的速度更快。这种目标获取的改善可能是由于注视质量提高，导致OMS输入的固有变化减少。一个经过改进的行为性OMS模型，具有“快”和“慢”运动神经元通路以及更符合生理的眼球运动系统，成功预测了这种改善的视觉行为，并再次证明了其在指导眼动研究中的实用性。
