Araya J C, Duarte I, Llanos O, Guzmán S
Departamento de Anatomía Patológica, Escuela de Medicina, P Universidad Católica de Chile, Santiago de Chile.
Rev Med Chil. 1991 May;119(5):499-505.
Eleven gastric mucosal defects produced by endoscopic biopsy in non-tumoral areas were histologically studied in gastrectomy specimens. The biopsies had been performed from one up to seven days before the operation. The base of each defect was formed by submucosa infiltrated by erythrocytes, fibrin and neutrophils, which were later replaced by small blood vessels, fibroblasts and collagen fibrils. The mucosa of the margins bowed down towards the base of the defect. This marginal mucosa showed dedifferentiation of the glandular epithelial cells, increased mitotic index and some cystic glandular structures lined by basophilic cells. The defect was progressively covered by a layer of flattened or cuboidal cells in which no mitoses were observed; their cytoplasm contained mucosubstances similar to those of the superficial epithelium of the remaining mucosa, either foveolar- or intestinal metaplastic-type. From this layer, simple gland-like invaginations to the underlying connective tissue were observed. The findings are consistent with the regenerative events described in experimental gastric ulcers in animals. The method employed may be useful to study specific aspects on the regeneration of the human gastric mucosa.
对11例非肿瘤区域内镜活检所致胃黏膜缺损进行了胃切除标本的组织学研究。活检在手术前1至7天进行。每个缺损的底部由被红细胞、纤维蛋白和中性粒细胞浸润的黏膜下层构成，随后被小血管、成纤维细胞和胶原纤维所取代。边缘的黏膜向缺损底部弯曲。这种边缘黏膜显示腺上皮细胞去分化、有丝分裂指数增加以及一些由嗜碱性细胞衬里的囊性腺结构。缺损逐渐被一层扁平或立方形细胞覆盖，在这些细胞中未观察到有丝分裂；它们的细胞质含有与其余黏膜浅表上皮（胃小凹型或肠化生型）相似的黏液物质。从这一层观察到向下方结缔组织的简单腺样内陷。这些发现与动物实验性胃溃疡中描述的再生过程一致。所采用的方法可能有助于研究人类胃黏膜再生的特定方面。
