Abumohor P, Cerda C, Neira O, Palma S, Alvarado M A, Basualdo J, Bravo M, Guzmán L
Departamento de Medicina, Facultad de Medicina, Universidad de Chile (División Oriente), Santiago de Chile.
Rev Med Chil. 1991 May;119(5):517-23.
Anti-cardiolipin antibodies have been recently described in patients with systemic lupus erythematosus and other autoimmune disorders. Venous and arterial thrombosis, thrombocytopenia and recurrent abortion have been associated to the presence of these antibodies. Among 161 patients with systemic lupus we found 66% with anticardiolipin antibodies, mostly IgG type. Thrombosis and thrombocytopenia were more frequent in these patients (p < 0.05), especially among those with high titers. No association was found with central nervous system involvement, recurrent abortion, antinuclear or anti-DNA antibodies nor positivity for VDRL. These results support the frequent presence of anti-cardiolipin antibodies in patients with systemic lupus and their association to thrombosis and thrombocytopenia.
抗心磷脂抗体最近在系统性红斑狼疮和其他自身免疫性疾病患者中被发现。静脉和动脉血栓形成、血小板减少症和反复流产与这些抗体的存在有关。在161例系统性红斑狼疮患者中，我们发现66%的患者存在抗心磷脂抗体，大多数为IgG型。这些患者中血栓形成和血小板减少症更为常见（p<0.05），尤其是在高滴度患者中。未发现与中枢神经系统受累、反复流产、抗核或抗DNA抗体以及VDRL阳性有关。这些结果支持系统性红斑狼疮患者中抗心磷脂抗体的频繁存在及其与血栓形成和血小板减少症的关联。
