Basiri Zahra, Gholyaf Mahmoud, Faridnia Mansureh, Nadi Ebrahim, Bairanvand Mandana
Department of Internal Medicine, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran.
Acta Med Iran. 2013;51(1):35-40.
The central immunological disturbance in systemic lupus erythematosus (SLE) is autoantibody production. Some of these antibodies affecting components of the cell nucleus are the major characteristics of SLE. The present study was aimed to assess importance of anticardiolipin (ACL) antibody and its association with clinical state in SLE patients. A cross sectional study was performed on 100 patients with SLE referred to rheumatology outpatient clinic in Ekbatan hospital in Hamadan (Iran) between 2007 and 2008. Serum samples were extracted and screened for IgG and IgM using an ACL enzyme-linked immunosorbent assay. Up to 36% of patients were positive for ACL antibody that was more frequent in women than men (39.8% versus 8.3%). No association was revealed between ACL antibody and age. Clinical manifestations of antiphospholipid antibody syndrome were observed in 23.0% of patients that was more prevalent in ACL positive group compared with ACL negative group (41.7% versus 125%). The prevalence of other manifestations including pregnancy-related disorders (recurrent abortion), central nervous system defects, and deep vein thrombosis was 33.3%, 25.0%, and 30.6% in ACL positive group and was 9.4%, 7.8%, and 7.8% in ACL negative group that all were more frequent in the former group. The prevalence of thrombocytopenia was also higher in ACL positive group than another group (22.2% versus 15.6%). Among ACL positive patients with clinical manifestations of antiphospholipid antibody syndrome, 86.6% had medium to high titer of ACL. Our study emphasized value of (ACL) antibody to assess clinical status in SLE patients.
系统性红斑狼疮（SLE）的核心免疫紊乱是自身抗体产生。其中一些影响细胞核成分的抗体是SLE的主要特征。本研究旨在评估抗心磷脂（ACL）抗体的重要性及其与SLE患者临床状态的关联。2007年至2008年期间，对转诊至伊朗哈马丹市埃克巴坦医院风湿病门诊的100例SLE患者进行了一项横断面研究。提取血清样本，使用ACL酶联免疫吸附测定法检测IgG和IgM。高达36%的患者ACL抗体呈阳性，女性比男性更常见（39.8%对8.3%）。未发现ACL抗体与年龄之间存在关联。23.0%的患者出现抗磷脂抗体综合征的临床表现，ACL阳性组比ACL阴性组更普遍（41.7%对125%）。ACL阳性组中其他表现的患病率，包括与妊娠相关的疾病（反复流产）、中枢神经系统缺陷和深静脉血栓形成，分别为33.3%、25.0%和30.6%，而ACL阴性组分别为9.4%、7.8%和7.8%，所有这些在前一组中都更常见。ACL阳性组血小板减少症的患病率也高于另一组（22.2%对15.6%）。在有抗磷脂抗体综合征临床表现的ACL阳性患者中，86.6%的患者ACL滴度为中到高。我们的研究强调了（ACL）抗体在评估SLE患者临床状态方面的价值。
