Oddó D, Chuaqui R, Hofmann E, García M
Departamento de Anatomía Patológica, Escuela de Medicina, Pontificia Universidad Católica de Chile, Santiago de Chile.
Rev Med Chil. 1991 May;119(5):559-63.
A 24 year old man with AIDS diagnosed in 1989 and a history of several episodes of pulmonary pneumocystosis developed chronic diarrhea and severe epigastric pain. Endoscopy revealed a granular intestinal mucosa. There was atrophy of villi and Giemsa, Ziehl-Nielsen and Gram staining identified 1.5 to 2 u spores in the cytoplasm of intestinal cells. Transmission electron microscopy of the spores revealed a thick wall, a sporoplasm with a nucleus, ribosomes, a posterior vacuole and a polar filament with multiple coils; no mitochondria were seen. Thus, the patient had intestinal microsporidiosis caused by Enterocytozoon bieneusi. This is a rare pathogen recently identified in man.
一名24岁男性，1989年被诊断为艾滋病，有多次肺孢子菌肺炎发作史，出现慢性腹泻和严重上腹部疼痛。内镜检查显示肠黏膜呈颗粒状。存在绒毛萎缩，吉姆萨染色、齐尔-尼尔森染色和革兰氏染色在肠细胞胞质中发现1.5至2微米的孢子。孢子的透射电子显微镜检查显示有厚壁、带有细胞核、核糖体、后液泡和具有多个螺旋的极丝的孢子质；未见线粒体。因此，该患者患有由比氏肠微孢子虫引起的肠道微孢子虫病。这是一种最近在人类中发现的罕见病原体。
