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Expression of calcyclin-binding protein/Siah-1 interacting protein in normal and malignant human tissues: an immunohistochemical survey.钙周期蛋白结合蛋白/Siah-1相互作用蛋白在正常和恶性人体组织中的表达：一项免疫组织化学研究。
J Histochem Cytochem. 2008 Aug;56(8):765-72. doi: 10.1369/jhc.2008.950519. Epub 2008 Apr 28.
2
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Expression and clinical significance of CacyBP/SIP in pancreatic cancer.CacyBP/SIP在胰腺癌中的表达及临床意义
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CacyBP/SIP nuclear translocation regulates p27Kip1 stability in gastric cancer cells.CacyBP/SIP核转位调节胃癌细胞中p27Kip1的稳定性。
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Role of the CacyBP/SIP protein in gastric cancer.CacyBP/SIP蛋白在胃癌中的作用。
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CacyBP/SIP protein promotes proliferation and G1/S transition of human pancreatic cancer cells.CacyBP/SIP 蛋白促进人胰腺癌细胞的增殖和 G1/S 期转换。
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The potential role of CacyBP/SIP in tumorigenesis.CacyBP/SIP在肿瘤发生中的潜在作用。
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CacyBP/SIP, a calcyclin and Siah-1-interacting protein, binds EF-hand proteins of the S100 family.CacyBP/SIP是一种与钙周期蛋白和Siah-1相互作用的蛋白，可与S100家族的EF手型蛋白结合。
J Biol Chem. 2002 Aug 9;277(32):28848-52. doi: 10.1074/jbc.M203602200. Epub 2002 May 31.
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CacyBP/SIP protein is important for the proliferation of human glioma cells.CacyBP/SIP蛋白对人类胶质瘤细胞的增殖很重要。
IUBMB Life. 2014 Apr;66(4):286-91. doi: 10.1002/iub.1263. Epub 2014 Apr 17.

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CACYBP expression predicts prognosis in hepatocellular carcinoma: A meta-analysis and bioinformatics validation.钙周期蛋白结合蛋白（CACYBP）表达可预测肝细胞癌的预后：一项荟萃分析及生物信息学验证
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The Effect of CacyBP/SIP on the Phosphorylation of ERK1/2 and p38 Kinases in Clear Cell Renal Cell Carcinoma.CacyBP/SIP 对肾透明细胞癌细胞中 ERK1/2 和 p38 激酶磷酸化的影响。
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Comparative Assessment of the WNT/β-Catenin Pathway, CacyBP/SIP, and the Immunoproteasome Subunit LMP7 in Various Histological Types of Renal Cell Carcinoma.肾细胞癌不同组织学类型中WNT/β-连环蛋白信号通路、CacyBP/SIP及免疫蛋白酶体亚基LMP7的比较评估
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CacyBP/SIP promotes tumor progression by regulating apoptosis and arresting the cell cycle in osteosarcoma.CacyBP/SIP通过调节细胞凋亡和使骨肉瘤细胞周期停滞来促进肿瘤进展。
Exp Ther Med. 2020 Aug;20(2):1397-1404. doi: 10.3892/etm.2020.8843. Epub 2020 Jun 5.
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CACYBP Enhances Cytoplasmic Retention of P27 to Promote Hepatocellular Carcinoma Progression in the Absence of RNF41 Mediated Degradation.在缺乏RNF41介导的降解作用时，CACYBP增强P27的细胞质滞留以促进肝细胞癌进展。
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本文引用的文献

1
Establishment and characterization of calcyclin binding protein (CacyBP) monoclonal antibody.钙周期蛋白结合蛋白（CacyBP）单克隆抗体的制备与鉴定
Hybridoma (Larchmt). 2006 Apr;25(2):91-4. doi: 10.1089/hyb.2006.25.91.
2
Regulation of drug sensitivity of gastric cancer cells by human calcyclin-binding protein (CacyBP).人钙周期蛋白结合蛋白（CacyBP）对胃癌细胞药物敏感性的调控
Gastric Cancer. 2004;7(3):160-6. doi: 10.1007/s10120-004-0286-3.
3
[Prokaryotic expression of human calcyclin-binding protein and preparation of mouse polyclonal antibody against hCacyBP].人钙周期蛋白结合蛋白的原核表达及抗人CacyBP小鼠多克隆抗体的制备
Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2004 Mar;20(2):206-9.
4
Translocation and phosphorylation of calcyclin binding protein during retinoic acid-induced neuronal differentiation of neuroblastoma SH-SY5Y cells.视黄酸诱导神经母细胞瘤SH-SY5Y细胞神经元分化过程中钙周期蛋白结合蛋白的易位与磷酸化
J Biochem Mol Biol. 2003 Jul 31;36(4):354-8. doi: 10.5483/bmbrep.2003.36.4.354.
5
Differentially expressed gene profiles between multidrug resistant gastric adenocarcinoma cells and their parental cells.多药耐药性胃腺癌细胞与其亲本细胞之间的差异表达基因谱。
Cancer Lett. 2002 Nov 28;185(2):211-8. doi: 10.1016/s0304-3835(02)00264-1.
6
CacyBP/SIP, a calcyclin and Siah-1-interacting protein, binds EF-hand proteins of the S100 family.CacyBP/SIP是一种与钙周期蛋白和Siah-1相互作用的蛋白，可与S100家族的EF手型蛋白结合。
J Biol Chem. 2002 Aug 9;277(32):28848-52. doi: 10.1074/jbc.M203602200. Epub 2002 May 31.
7
Ca2+-dependent translocation of the calcyclin-binding protein in neurons and neuroblastoma NB-2a cells.神经元和神经母细胞瘤NB-2a细胞中钙调蛋白结合蛋白的钙依赖性易位。
J Biol Chem. 2002 Jun 7;277(23):21103-9. doi: 10.1074/jbc.M111010200. Epub 2002 Apr 1.
8
Siah-1, SIP, and Ebi collaborate in a novel pathway for beta-catenin degradation linked to p53 responses.Siah-1、SIP和Ebi在一条与p53反应相关的β-连环蛋白降解新途径中协同作用。
Mol Cell. 2001 May;7(5):915-26. doi: 10.1016/s1097-2765(01)00242-8.
9
Molecular cloning and expression of a mouse brain cDNA encoding a novel protein target of calcyclin.编码钙周期蛋白一种新型蛋白质靶点的小鼠脑cDNA的分子克隆与表达
J Neurochem. 1998 May;70(5):1793-8. doi: 10.1046/j.1471-4159.1998.70051793.x.
10
SKP1 connects cell cycle regulators to the ubiquitin proteolysis machinery through a novel motif, the F-box.SKP1通过一种新的基序——F盒，将细胞周期调节因子与泛素蛋白水解机制连接起来。
Cell. 1996 Jul 26;86(2):263-74. doi: 10.1016/s0092-8674(00)80098-7.

钙周期蛋白结合蛋白/Siah-1相互作用蛋白在正常和恶性人体组织中的表达：一项免疫组织化学研究。

Expression of calcyclin-binding protein/Siah-1 interacting protein in normal and malignant human tissues: an immunohistochemical survey.

作者信息

Zhai Huihong, Shi Yongquan, Jin Haifeng, Li Yuanfei, Lu Yuanyuan, Chen Xiong, Wang Jinbo, Ding Liping, Wang Xin, Fan Daiming

机构信息

State Key Laboratory of Cancer Biology, Institute of Digestive Diseases, Xijing Hospital, Fourth Military Medical University, Xi'an 710032, China.

出版信息

J Histochem Cytochem. 2008 Aug;56(8):765-72. doi: 10.1369/jhc.2008.950519. Epub 2008 Apr 28.

DOI:10.1369/jhc.2008.950519
PMID:18443365
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2443607/
Abstract

Calcyclin-binding protein (CacyBP)/Siah-1 interacting protein (SIP), a component of ubiquitin-mediated proteolysis, could bind the Skp1-Cul1-F box protein complex. Although CacyBP/SIP was implicated in p53-induced beta-catenin degradation, its exact function was still unknown. Our previous studies showed that CacyBP/SIP could modulate the multidrug-resistant phenotype of gastric cancer cells and was highly expressed in gastric cancer tissues compared with that in non-cancerous tissues. In this study, CacyBP/SIP protein expression profile in a broad range of human normal tissues and carcinomas was analyzed by immunohistochemistry staining with anti-CacyBP/SIP monoclonal antibody first produced in our laboratory. CacyBP/SIP was generally localized in the cytoplasm/nucleus. Positive staining of CacyBP/SIP was found in brain, heart, lymph node, and esophagus. Weak staining was shown in the rectum and kidney. No CacyBP/SIP was detected in other normal tissues. However, CacyBP/SIP was ubiquitously detected in all kinds of tumor tissues and was highly expressed in nasopharyngeal carcinoma, osteogenic sarcoma, and pancreatic cancer. To our knowledge, this is the first study on the CacyBP/SIP expression pattern in a broad range of human normal and tumor tissues. The data presented should serve as a useful reference for other investigators in future studies of CacyBP/SIP functions. Hopefully, this knowledge will lead to discovery of more roles of CacyBP/SIP in tumorigenesis.

摘要

钙周期蛋白结合蛋白（CacyBP）/Siah-1相互作用蛋白（SIP）是泛素介导的蛋白水解的一个组成部分，它可以与Skp1-Cul1-F盒蛋白复合物结合。尽管CacyBP/SIP与p53诱导的β-连环蛋白降解有关，但其确切功能仍不清楚。我们之前的研究表明，CacyBP/SIP可以调节胃癌细胞的多药耐药表型，并且与非癌组织相比，在胃癌组织中高表达。在本研究中，首先用我们实验室制备的抗CacyBP/SIP单克隆抗体通过免疫组织化学染色分析了CacyBP/SIP蛋白在广泛的人类正常组织和癌组织中的表达谱。CacyBP/SIP通常定位于细胞质/细胞核。在脑、心脏、淋巴结和食管中发现了CacyBP/SIP的阳性染色。在直肠和肾脏中显示弱阳性染色。在其他正常组织中未检测到CacyBP/SIP。然而，在所有类型的肿瘤组织中都普遍检测到CacyBP/SIP，并且在鼻咽癌、骨肉瘤和胰腺癌中高表达。据我们所知，这是首次关于CacyBP/SIP在广泛的人类正常和肿瘤组织中表达模式的研究。所呈现的数据应为其他研究人员未来对CacyBP/SIP功能的研究提供有用的参考。希望这些知识将有助于发现CacyBP/SIP在肿瘤发生中的更多作用。