Kayhan Fatma Tülin, Algün Zeynep
Department of Otolaryngology, Bakirköy Dr. Sadi Konuk Training and Research Hospital, Istanbul, Turkey.
Kulak Burun Bogaz Ihtis Derg. 2008;18(1):14-8.
We evaluated the effect of naproxen sodium on propylene glycol-induced otitis media in guinea pig ears.
Twenty adult guinea pigs were randomized to the study and control groups equal in number. A single dose of propylene glycol (0.2 ml, 60%) was applied to the left ears of the control group and to both ears of the study group. Saline solution was applied to the right ears of the control group. After propylene glycol application, the study group received naproxen sodium (oral, 10 mg/kg daily) for 15 days, whereas the control ears were left untreated. At the end of four weeks, the animals were decapitated under anesthesia. Otoscopic examination was performed and temporal bones were removed for histologic examination under light microscopy.
Nine animals were alive in each group at the end of four weeks. In the control group, all the right ears receiving saline solution were normal, whereas otitis media and inflammatory changes were observed in six of the left ears receiving propylene glycol. In the study animals treated with naproxen sodium, otitis media and tympanic membrane perforation were seen in 14 ears. Of these, three ears had purulent, 11 ears had serous effusion. Epithelial hyperplasia (n=10), keratinizing epithelium and cholesteatoma formation (n=4) were also observed.
Our results suggest that the administered dose of systemic naproxen sodium has no inhibitory effect on the development of inflammation and otitis media.
我们评估了萘普生钠对豚鼠耳朵中丙二醇诱导的中耳炎的影响。
将20只成年豚鼠随机分为数量相等的研究组和对照组。对照组的左耳和研究组的双耳均单次给予丙二醇（0.2 ml，60%）。对照组的右耳给予生理盐水。给予丙二醇后，研究组接受萘普生钠（口服，每日10 mg/kg），持续15天，而对照耳不进行治疗。四周结束时，在麻醉下将动物断头。进行耳镜检查，并取出颞骨进行光学显微镜下的组织学检查。
四周结束时每组有9只动物存活。在对照组中，所有接受生理盐水的右耳均正常，而在接受丙二醇的左耳中有6只出现了中耳炎和炎症变化。在用萘普生钠治疗的研究动物中，14只耳朵出现了中耳炎和鼓膜穿孔。其中，3只耳朵有脓性分泌物，11只耳朵有浆液性渗出。还观察到上皮增生（n = 10）、角化上皮和胆脂瘤形成（n = 4）。
我们的结果表明，全身给予萘普生钠的剂量对炎症和中耳炎的发展没有抑制作用。
