表面增强拉曼光谱——一种用于生物分析的单分子和纳米级工具。
SERS--a single-molecule and nanoscale tool for bioanalytics.
作者信息
Kneipp Janina, Kneipp Harald, Kneipp Katrin
机构信息
Harvard University Medical School, Wellman Center for Photomedicine, Boston, MA 02114, USA.
出版信息
Chem Soc Rev. 2008 May;37(5):1052-60. doi: 10.1039/b708459p. Epub 2008 Mar 20.
Surface enhanced Raman scattering (SERS) at extremely high enhancement level turns the weak inelastic scattering effect of photons on vibrational quantum states into a structurally sensitive single-molecule and nanoscale probe. The effect opens up exciting opportunities for applications of vibrational spectroscopy in biology. The concept of SERS can be extended to two-photon excitation by exploiting surface enhanced hyper-Raman scattering (SEHRS). This critical review introduces the physics behind single-molecule SERS and discusses the capabilities of the effect in bioanalytics (100 references).
极高增强水平的表面增强拉曼散射（SERS）将光子对振动量子态的微弱非弹性散射效应转变为一种对结构敏感的单分子和纳米级探针。这一效应为振动光谱学在生物学中的应用开辟了令人兴奋的机会。通过利用表面增强超拉曼散射（SEHRS），SERS的概念可以扩展到双光子激发。这篇综述介绍了单分子SERS背后的物理原理，并讨论了该效应在生物分析中的能力（参考文献100篇）。
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