Quan Yanxiao, Weng Guojun, Zhu Jian, Li Jianjun, Zhao Junwu
The Key Laboratory of Biomedical Information Engineering of Ministry of Education, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an, China.
Mikrochim Acta. 2025 Mar 3;192(3):200. doi: 10.1007/s00604-025-07055-7.
Surface-enhanced Raman scattering (SERS) has emerged as a powerful tool for trace substances detection due to its exceptional sensitivity, high anti-interference capability, and ease of operation, enabling detection at the single-molecule level. This makes SERS particularly promising for applications such as environmental monitoring, biomedical diagnostics, and food safety. Despite these advantages, SERS faces limitations due to the difficulty of enriching trace substances and the small Raman scattering cross sections of certain molecules. Metal-organic frameworks (MOFs), characterized by their high surface areas and porosity, tunable structures, and diverse functionalities, offer a promising solution to these challenges. By integrating MOFs with SERS technology, we explore how MOF-based SERS probes can enhance the sensitivity, selectivity, and efficiency of trace substance detection through mechanisms such as analyte enrichment, selective molecular capture, and electromagnetic field manipulation. In this paper, a comprehensive review of the structure and synthesis of MOF-SERS composites is presented, with an emphasis on their application in the detection of trace substances. The paper also discusses key challenges in the design and optimization of MOF-based SERS probes, particularly in terms of stability, reproducibility, and integration with existing detection platforms, aiming to broaden their practical applications and improve their detection efficiency.
表面增强拉曼散射（SERS）因其卓越的灵敏度、高抗干扰能力和易于操作等特点，已成为痕量物质检测的有力工具，能够实现单分子水平的检测。这使得SERS在环境监测、生物医学诊断和食品安全等应用领域具有特别广阔的前景。尽管具有这些优势，但由于痕量物质富集困难以及某些分子的拉曼散射截面较小，SERS仍面临局限性。金属有机框架（MOF）具有高比表面积和孔隙率、可调控结构以及多样的功能特性，为应对这些挑战提供了一个有前景的解决方案。通过将MOF与SERS技术相结合，我们探索基于MOF的SERS探针如何通过分析物富集、选择性分子捕获和电磁场操纵等机制来提高痕量物质检测的灵敏度、选择性和效率。本文对MOF-SERS复合材料的结构和合成进行了全面综述，重点介绍了它们在痕量物质检测中的应用。本文还讨论了基于MOF的SERS探针设计和优化中的关键挑战，特别是在稳定性、重现性以及与现有检测平台集成方面，旨在拓宽其实际应用并提高检测效率。
