Shen Xiao Z, Xiao Hong D, Li Ping, Lin Chentao X, Billet Sandrine, Okwan-Duodu Derick, Adams Jon W, Bernstein Ellen A, Xu Yi, Fuchs Sebastien, Bernstein Kenneth E
Department of Pathology, Emory University, 101 Woodruff Circle, Atlanta, GA 30322, USA.
J Mol Med (Berl). 2008 Jun;86(6):679-84. doi: 10.1007/s00109-008-0325-3. Epub 2008 Apr 29.
Angiotensin-converting enzyme (ACE) has been well-recognized for its role in blood pressure regulation. ACE is made by many tissues, though it is most abundantly expressed on the luminal surface of vascular endothelium. ACE knockout mice show a profound phenotype with low blood pressure, but also with hemopoietic and developmental defects, which complicates understanding the biological functions of ACE in individual tissue types. Using a promoter-swapping strategy, several mouse lines with unique ACE tissue expression patterns were studied. These include mice with ACE expression in the liver (ACE 3/3), the heart (ACE 8/8), and macrophages (ACE 10/10). We also investigated mice with a selective inactivation of either the N- or C-terminal ACE catalytic domain. Our studies indicate that ACE plays a role in many other physiologic processes beyond simple blood pressure control.
血管紧张素转换酶（ACE）在血压调节中的作用已得到充分认识。ACE由许多组织产生，不过它在血管内皮的腔面表达最为丰富。ACE基因敲除小鼠表现出严重的表型，血压低，同时还有造血和发育缺陷，这使得了解ACE在个体组织类型中的生物学功能变得复杂。利用启动子交换策略，研究了几种具有独特ACE组织表达模式的小鼠品系。其中包括在肝脏中表达ACE的小鼠（ACE 3/3）、在心脏中表达ACE的小鼠（ACE 8/8）以及在巨噬细胞中表达ACE的小鼠（ACE 10/10）。我们还研究了选择性失活N端或C端ACE催化结构域的小鼠。我们的研究表明，ACE在简单的血压控制之外的许多其他生理过程中也发挥作用。
