Kwiek Jesse J, Arney Leslie A, Harawa Visopo, Pedersen Bonnie, Mwapasa Victor, Rogerson Stephen J, Meshnick Steven R
Department of Epidemiology, University of North Carolina, Chapel Hill, NC, USA.
J Infect Dis. 2008 May 15;197(10):1378-81. doi: 10.1086/587646.
The mechanism of mother-to-child transmission (MTCT) of HIV-1 is not well described.
Of 328 HIV-infected mother-infant pairs, we identified 91 that had discordant angiotensin I-converting enzyme and glutathione S-transferase M1 alleles. Maternal alleles in cord blood were quantified with real-time polymerase chain reaction, as indicators of microtransfusions.
HIV-1 infected infants had more maternal DNA in cord blood than their uninfected counterparts. Increased maternal DNA in cord blood was associated with preterm delivery, low birth weight, and maternal immunosuppression.
Intrapartum MTCT was associated with placental microtransfusions. The associations among placental microtransfusion, in-utero MTCT, maternal immunosuppression, and poor birth outcome should be further investigated.
HIV-1母婴传播(MTCT)的机制尚未得到充分描述。
在328对感染HIV的母婴对中,我们鉴定出91对母婴的血管紧张素I转换酶和谷胱甘肽S-转移酶M1等位基因不一致。用实时聚合酶链反应对脐带血中的母本等位基因进行定量,作为微量输血的指标。
感染HIV-1的婴儿脐带血中的母本DNA比未感染的婴儿更多。脐带血中母本DNA增加与早产、低出生体重和母亲免疫抑制有关。
分娩期MTCT与胎盘微量输血有关。胎盘微量输血、宫内MTCT、母亲免疫抑制和不良出生结局之间的关联应进一步研究。