Keynan Yoav, Card Catherine M, McLaren Paul J, Dawood Magdy R, Kasper Ken, Fowke Keith R
Department of Medical Microbiology, University of Manitoba, Winnipeg, Canada.
Clin Infect Dis. 2008 Apr 1;46(7):1046-52. doi: 10.1086/529379.
Regulatory T cells, a subset of CD4(+) T lymphocytes, play a pivotal role in the maintenance of the balance between the tissue-damaging and protective effects of the immune response. These cells have immunosuppressive function and have been intensely studied in the context of autoimmunity, cancer, allergies, asthma, and infectious diseases. Their role in chronic and persistent viral infections is well appreciated. In acute viral infections, the function of these cells is still unclear. The host and pathogen factors that control the generation and activity of regulatory T cells and the role of these cells in modulating expansion, contraction, and development of immune memory in acute respiratory virus infection need to be further elucidated.
调节性T细胞是CD4(+) T淋巴细胞的一个亚群，在维持免疫反应的组织损伤和保护作用之间的平衡中起关键作用。这些细胞具有免疫抑制功能，并且在自身免疫、癌症、过敏、哮喘和传染病等背景下受到了深入研究。它们在慢性和持续性病毒感染中的作用已得到充分认识。在急性病毒感染中，这些细胞的功能仍不清楚。控制调节性T细胞产生和活性的宿主和病原体因素，以及这些细胞在急性呼吸道病毒感染中调节免疫记忆的扩增、收缩和发育的作用，需要进一步阐明。
