Dillner Lena, Pagliusi Sonia, Bray Freddie, Lorincz Attila, Kjaer Susanne K, Anttila Ahti, Iversen Ole Eric, Dillner Joakim, Lehtinen Matti, Paavonen Jorma
WHO Global Reference Laboratory for HPV Diagnosis and Control, Department of Clinical Microbiology, University Hospital, Malmö, Sweden.
Acta Obstet Gynecol Scand. 2008;87(5):489-98. doi: 10.1080/00016340801986771.
Disease trend studies based on birth cohort analysis and serological studies indicate that recent generations have a higher prevalence of oncogenic Human Papilloma Virus (HPV) types, and are likely to be at higher risk of cancer than previous generations. This implies that prevention strategies to protect young populations from HPV-associated cancers need to be strengthened, and hence organized implementation of vaccination and better screening programs are being considered. In this context, randomized large-scale policy evaluations will be instrumental in accelerating disease control and improve effective prevention programs. This report shares experiences from Nordic countries with examples of prevention strategies through vaccination and cervical screening. The same principles as set up for organized programs and new HPV technologies may apply for screening and vaccination as key tools to eliminate cervical cancer in the Nordic countries and globally.
基于出生队列分析和血清学研究的疾病趋势研究表明,与前几代人相比,当代人群中致癌性人乳头瘤病毒(HPV)类型的流行率更高,患癌风险也可能更高。这意味着需要加强保护年轻人群免受HPV相关癌症侵害的预防策略,因此正在考虑有组织地实施疫苗接种和更好的筛查计划。在这种背景下,随机大规模政策评估将有助于加速疾病控制并改进有效的预防计划。本报告分享了北欧国家通过疫苗接种和宫颈癌筛查实施预防策略的经验。为有组织的计划和新的HPV技术制定的相同原则,可能适用于将筛查和疫苗接种作为北欧国家及全球消除宫颈癌的关键工具。