Satarasinghe R L, Ramesh R, Riyaaz A A A, Gunarathne P A K G, de Silva A P
Sri Jayewardenepura General Hospital, Kotte, Sri Lanka.
Drug Metabol Drug Interact. 2007;22(4):279-83. doi: 10.1515/dmdi.2007.22.4.279.
A literature survey reveals that both lipid lowering drugs - statins and fibrates--and hypothyroidism are documented causes of muscle disorders including rhabdomyolysis leading to acute renal failure. We describe a case of fenofibrate monotherapy (Lipicard) induced dialysis dependent acute renal failure in an undiagnosed hypothyroid patient which is the first case to be reported from Sri Lanka. We strongly recommend that all patients who are receiving statins and/or fibrates should be screened for occult hypothyroidism which seems to aggravate the muscle damage due to the above drugs, with or without other risk factors.
一项文献调查显示，降脂药物——他汀类药物和贝特类药物——以及甲状腺功能减退都是有记录的导致肌肉疾病的原因，包括横纹肌溶解症进而导致急性肾衰竭。我们描述了一例在未确诊甲状腺功能减退的患者中，非诺贝特单药治疗（立平脂）导致依赖透析的急性肾衰竭的病例，这是斯里兰卡报道的首例此类病例。我们强烈建议，所有正在接受他汀类药物和/或贝特类药物治疗的患者都应接受隐匿性甲状腺功能减退的筛查，因为无论有无其他风险因素，隐匿性甲状腺功能减退似乎都会加重上述药物所致的肌肉损伤。
